acid base imbalances Flashcards
acid
electrolyte with ions in water to form hydrogen ions and anions
base
a substance that can bind to hydrogen ions
normal blood pH
7.35-7.45
What blood pH does death occur
less than 6.8
over 7.8
volatile acids
can be exerted from the body as a gas
Nonvolatile acids
Must be excreted via kidneys as liquid
Lactic acid, ketones, phosphoric acid, sulfuric acid
Typical american diet causes overload
Excretion of acids
Lungs excrete volatile (CO2)
Kidney excrete nonvolatile and retain bicarb as a buffer for acids (eliminate H+ and generate HCO3-)
CO2 and HCO3- acid or base
CO2 acid
HCO3- base
High CO2
Hypercapnia
increased ventilation
Low CO2
Hypocapnia
decreases ventilation
What do kidneys excrete and retain
Excrete H+ ions attached to NH4 (ammonia)
Retain sodium bicarb (most common buffer
Lab findings of respiratory acidosis
pH below 7.35
CO2> 45mm Hg
HCO3 normal
Urine pH below 6
Manifestations of resp acidosis
Neuro drowsy, disoriented, coma
Cardio hypotension, tachy
respiratory shallow, tachy/brady
Muscular: weakness
Causes of respiratory alkalosis
Hyperventilation (anxiety, encephalitis, fever, mechanical overventilation)
La values for respiratory alkadosis
pH >7.45
CO2 <35mmHg
HCO3 normal
Urine pH >7
Manifestations of respiratory alkalosis
Lethargic
confused
numbness
tingling
Muscular: tetany, hyperreflexia
Respiratory: hyperventilation
causes of metabolic acidosis
Excess production of acids (diabetic ketoacidosis, lactic aciosis, starvation with lactic acidosis)
Inadequate loss of acids (uremia, renal tubular acidosis)
Excessive loss of base (severe diarrhea)
Lab findings in metabolic acidosis
pH <7.35
CO2 normal
HCO2 <24
Urine pH <6
Manifestations of metabolic acidosis neuro GI resp
Neuro: disoriented, weak, coma
GI: nausea, vomiting, diarrhea, abdominal pain, dehydration
Resp: hyperventilation
causes of metabolic alkalosis
Loss of acids (severe vomiting, excess gastric suctioning, diuretic therapy)
Base or buffer imbalance (K+ deficit causing Na+ excess)
Excessive bicarb intake
Lab findings of metabolic alkadosis
pH>7.45
CO2 normal
HCO3 >24
Urine pH >7
Normal values (Co2, pH, HCO3, Hgb, CO)
CO2 38-43
pH 7.35-7.45
HCO3 22-26
Hgb 13-15
CO 0