ABX Flashcards
Broad spectrum PCN
Ampicillin
Interesting SE of ampicillin
Black tongue (thrush)
How is Ampicillin taken?
Empty stomach w/ water
Important Rx interactions w/ ampicillin?
Tetracycline - decreases the effectiveness
Allopurinol/Probencid - decreases elimination AND increases concentraion (effectiveness)
Which PCN combo is taken PO?
Amoxicillin/Clavulante
How is cefalozin taken?
With food
Purpose of cefalozin?
Presurgery Prophylaxis
Important Rx interactions w/ cefalozin?
Vancomycin and Aminoglycosides
What are alternatives to PCN allergies?
Impenem-Cilastatin
Vancomycin (PCN resistant)
Erythromycin
What class is cefalozin?
Cephalosporin
What class is Impenem-Cilastatin?
Carbapenems
Which Rx affect Liver Fx?
Impenem-Cilastatin
What class is Aztreonam?
Monobactams
Does Aztreonam work on GN or GP organisms?
GN and gentler on NF
Important Rx interactions w/ Aztreonam?
Aminoglycosides (Renal)
Furesemide (INC conc/effectiveness)
What class is gentamicin?
Aminoglycosides
Purpose of prescribing gentamicin?
Serious GN or anaerobic infections
Important gentamicin SE?
Ototoxic (permanent)
Nephrotoxic
Important RX interactions w/ gentamicin?
If combo w/ PCN - decrease dose
Vancomycin
Amphotercin B
Loop Diuretics
What class is Ciprofloxacin?
FLQ
What class is tetracycline hydrochloride?
Tetracyclines
What class is TMP-SMX?
Sulfonamides
What Rx is for anthrax infections/prophylaxis?
Ciprofloxacin
What Rx is associated with tendonitis/Achilles tendon rupture?
Ciprofloxacin
What Rx is associated with tooth discoloration?
Tetracycline hydrochloride
CI <8yo and PREG
What Rx is preferred for Pneumocystis Jiroveci (HIV inf)?
TMP-SMX
What medications are preferred for UTI’s?
TMP-SMX
Nitrofurantoin
What medications are CI for PEDS?
Ciprofloxacin (Not 1st L)
TMP-SMX (<2mo - kernictus)
Tetracycline Hydrochloride (Tooth discoloration)
What Rx prolongs QT Interval?
Ciprofloxacin
What Rx if combined w/ another Rx requires ACHS?
TMP-SMX and Sulfonylureas
What Rx is used to TXT uncomplicated UTI or prophylaxis for UTI’s?
Nitrofurantoin
Which Rx is not ABX and is used for UTI pain relief?
Phenazopyridine
What Rx is bacterial static?
Erythromycin
What Rx is used for STI eye infections in newborns as an ointment?
Erythromycin
What is erythromycin combined w/ to increase ability?
Streptomicin
What Rx is ototoxic?
Gentamicin (IRREV)
Erythromycin (REV)
Vancomycin
What Rx is associated with crystal build up and requires 1.5-3L of fluid?
TMP-SMX
What is an important SE of TMP-SMX?
SJS
What is an important SE of nitrofurantoin?
EKG - BBB - Wide QRS and ventricle issues
What Rx decreases WBC/PLT?
Phenazopyririnde
How is erythromycin taken?
Empty stomach with water
What is an important RX combination that could cause cardiac arrest?
Erythromycin and Diltizam or Fluconazole
What Rx is associated w/ disulfram reaction (ETOH)?
Metronidazole
What Rx combination is associated with serotonin syndrome?
Linezolid
- SSRI’s
- MAOI’s
- TCA’s
What Rx is a first line C-Diff TXT?
Metronidazole - (1 dose prophylaxis if abdominal surgery occurs quickly)
What Rx is extrapyridimal SE’s?
Metronidazole
What Rx can cause redman syndrome?
Vancomycin
What Rx can treat MRSA/VRE?
Linezolid
What Rx combination can be used for C-Diff?
Metronidazole (IV) and Vancomycin (PO)
What Rx can cause bone marrow suppression?
Linezolid
What Rx is for nonresistant and active TB infections only?
Rifampin
What Rx changes the colors of various body fluids?
Rifampin - Harmless
What Rx can cause optic neuritis?
Ethambutol - visual acuity monitoring
Which TB Rx is not hepatotoxic?
Ethambutol
What TB Rx should be taken with vitamins?
Isoniazid - B6
Which TB Rx causes a increasingly efficient liver?
Rifampin
Do not give these RXN for PCN allergies…
PCN, Cephalosporins, and Carbapenems
What monobactam is not cross sensitive with PCN?
Aztreonam
S/S and Steven Johnson syndrome (SJS)?
Malaise, low fever
Rash to Slough
What are S/S of redman syndrome?
Flush, HOTN
Rash
GIve >=60m diluted
Four 1st line TB Rx?
Isoniazid
Rifampin
Pyrazinamide
Ethanbutol
Four 2nd line TB Rx?
Levofloxacin (FLQ)
Moxifloxacin (FLQ)
Amikacin (Aminoglycoside)
Streptomycin (Macrolide)
TXT recommendation for latent TB infection?
TXT -
1 Rx for 9mo OR
2 Rx for 3mo
TXT recommendation for active TB infection?
TXT -
4 Rx for 2mo OR
2 Rx for 4mo
Rx affecting liver Fx
Carbapenems,
Erythromycin,
Isoniazid,
Rifampin,
Pyrazinamide
How to monitor LFTs?
Liver enzymes, TP, albumin, bilirubin
How to monitor Renal Fx?
Titrate - Check I/O - labs (Cr/BUN/SG) - Fluids
Rx causing C-Diff or yeast infections?
PCN, Cephs, Aztreonam, Tertacycline Hydrochloride, Erythromycin,
Rx that interact w/ metalllics?
Ciprofloxacin,
Tertacycline Hydrochloride,
Erythromycin
Rx that cause photosensitivity?
TMP-SMX,
Tertacycline Hydrochloride,
Ciprofloxacin