Abnormal leukocyte morphology Flashcards
What is this cell (normal dog)
Neutrophil
What is this cell (normal dog)
rubricyte
What is this cell (normal dog)
Monocyte
What are these cells (normal dog)
Basophil (top) eosinophil (bottom)
What is this cell (normal dog)
lymphocyte
What may be seen with toxic change?
Dohle bodies
Basophilic cytoplasm
Foamy vacuolated cytoplasm
Toxic granulation
Giant Neutrophils
When would you see ring form neutrophils?
- in healthy rodents
- intense inflammation
- chronic myeloid leukaemia
- myelodysplasia
What is toxic change?
Cytoplasmic immaturity due to hastened or disordered maturation in the bone marrow due to infection, myeloproliferative disease or intense inflammation
What is this cell?
Rabbit heterophil (neutrophil)
What is this cell?
Snake heterophil
Causes of hypersegmented neutrophils?
- Chronic glucocorticoid ecposure (decreased tissue emigration)
- Can be seen in myeloproliferative diseases eg. chronic granulocytic leukaemia
What is this cell?
Monocyte
What is this cell?
Metamyelocyte (toxic change neutrophil)
What are the following abnormalities in neutrophils?
Barr body -inactivated x chromosome in females
What are the following abnormalities in neutrophils?
Hypersegmentation
What are the following abnormalities in neutrophils?
Botryoid nucleus - heat stroke (cooked blood)
What are the following abnormalities in neutrophils?
Ring form with toxic change
What is this cell?
Myelocyte - neutrophil lineage as nucleus is that same colour as the other neutrophils
What is this cell?
Monocyte - vacuolated
What’s going on here?
Cow lymphocyte
- appears large but actually just has small RBCs
- It is a granular lymphocyte (cytotoxic T cell)
What;s going on here?
Foa-Kurloff cell - guinea pig
What’s going on here?
Erythrophagia - gobbling erythrocytes due to IMHA or transfusion
What’s going on here?
Sideroleukocyte (haemosiderin)
What’s happening here?
Bacterial inclusions
-degenerate neutrophils in the blood (normally only see them in the periphery)
What’s happening here?
Distemper virus inclusions (not normal to have these in RBCs)
What are these examples of?
Exotic diseases with leukocyte inclusions
What is Chediak-Higashi syndrome?
Hereditary disorder
- large fused granules in granulocytes
What is Pelger-Huet Anomaly?
Hereditary disorder
- failure of nuclear segmentation
- no toxic change
What is this cell?
Mast cell
round nucleus
Seen in neoplasia (not segmented)
granules
What is this cell? from greyhound
Eosinophil
- granules don’t stain
- grey cytoplasm
