Aani Micro: Hepatitis

Question 1

What family of virus is Hep A? What is the genetic material?

Answer 1

Picorna virus RNA

Question 2

What family of virus is Hep B? What is the genetic material?

Answer 2

Hepadna virus DNA

Question 3

What family of virus is Hep C? What is the genetic material?

Answer 3

Flavivirus RNA

Question 4

What is the incubation period for Hep A?

Answer 4

2-6 weeks

Question 5

What is the incubation period for Hep E?

Answer 5

3-8 weeks

Question 6

What is the difference in liver enzyme changes between Hep A B and C?

Answer 6

All have raised ALT

Hep B has raised AST

Question 7

What is the diagnostic test for Hep A?

Answer 7

Anti Hep A IgM antibodies

If they have IgG then they have had previous infection or the vaccine

Question 8

Treatment for Hep A?

Answer 8

Supportive

Question 9

Treatment for Hep B?

Answer 9

Peg IFN 2 alpha
Lamivudine suppressive therapy
If Hep B + HIV: Truvada (tenofovir and entricitabine)

Question 10

What are the complications of Hep B?

Answer 10

HCC
Cirrhosis

Same in Hep C

Question 11

What is the diagnostic test for active Hep B?

Answer 11

Hep B surface antigens will only be present in ACTIVE Hep B

Question 12

Which Abs do you develop upon being infected with Hep B?

Answer 12

CORE Abs- you will only have these in active infection (IgM( or previous infection (IgG)

Question 13

When do you get serum Abs in Hep B?

Answer 13

After first infection or after vaccination.

N.B. If it is previous infection you will also have core Abs but in vaccination you won’t have core abs.

Question 14

What are the particles of Hep B virus called?

Answer 14

Den particles

Question 15

Treatment of Hep C?

Answer 15

Peg IFN 2b

Ribavirin

Question 16

What stages of the virus life cycle do Hep C drugs affect?

Answer 16

Processing
Replication
Assembly

Question 17

Which drugs affect just processing of Hep C?

Answer 17

Drugs ending with PREvir

They are NS3 inhibitors

Question 18

Which drugs affect all the stages of Hep C?

Answer 18

Drugs ending with Avir

They are HS5A inhibitors

Question 19

Which drugs affect just the replication of Hep C?

Answer 19

Drugs ending with Buvir

NS5B inhibitors

Question 20

Which pts get Hep D?

Answer 20

Can only get it as a co-infection with Hep B

Question 21

Tx of Hep D?

Answer 21

IFN alpha/liver tranplant

Question 22

which Family of virus is Hep E?

Answer 22

Hepeviridae

Question 23

Which genotypes of Hep E affect humans?

Answer 23

1 + 2

Question 24

Complication of Hep E?

Answer 24

Bell’s palsy