A.7- mineralocorticoids. topically applied glucocorticoids Flashcards
how are topical GC classified?
based on potency: class I (very potent), class II (potent), class III (Moderate) class IV (mild)
list the topical GC agents
"Bless Family, Mother &Father" Budesonide Fluocinolone Mometasone Fluticasone
topical GC applications
- Dermatology (ointment)
- Allergic rhinitis (nasal spray)
- allergic conjunctivitis (eye drops)
- arthritis ( intra-articular injection)
- IBD’s (suppository preparations)
- asthma (inhaled preparations)
potential local adverse effects with long term administration of topical GC
skin atrophy, striae, rosacea, acne, purpura
duration of action of Aldosterone
very short (1-2h)
duration of action of fludrocortisone
short (8-12h)
what are aldosterone and fludrocortisone?
mineralocorticoids
which Mineralocorticoid has the highest Naᶧ retaining activity?
aldosterone-500
SE of mineralcorticoids
"CHER" Cardiac remodelling -->HF Hypertension Electrolyte abnormalities salt and fluid Retention
types of corticosteroid antagonists
receptor antagonists and synthesis inhibitors
what are spironolactone and eplerenone?
MC receptor antagonists
what is mifepristone?
GC receptor antagonit
how are the Corticosteroid receptor antagonists taken?
oral
why does spironolactone cause antiandrogenic effects?
it’s a weak antagonist of androgen receptor
indications of spironolactone
hyperaldosteronism
hypokalemia (caused by K wasting diuretics)
CHF
As Antiandrogenic (in PCOS)
SE of spironolactone
hyperkalemic metabolic acidosis, gynecomastia, impotence
why does mifepristone cause vaginal bleeding?
it is a potent inhibitor of progesterone receptor
indications of mifepristone
Cushing’s syndrome
medical abortion
SE of mifepristone
abdominal pain, headache, GI disturbances, vaginal bleeding
function of metyrapone
Inhibits 11β- hydroxylase - prevent synthesis of cortisol
function of etomidate
Inhibits 11β- hydroxylase
what is metyrapone used for?
diagnostic test of adrenal function
what is etomidate used for?
severe cushing’s syndrome
indications for ketoconazole
antifungal drug adrenal carcinoma hirsutism breast cancer prostate cancer
