A.7- mineralocorticoids. topically applied glucocorticoids Flashcards
how are topical GC classified?
based on potency: class I (very potent), class II (potent), class III (Moderate) class IV (mild)
list the topical GC agents
"Bless Family, Mother &Father" Budesonide Fluocinolone Mometasone Fluticasone
topical GC applications
- Dermatology (ointment)
- Allergic rhinitis (nasal spray)
- allergic conjunctivitis (eye drops)
- arthritis ( intra-articular injection)
- IBD’s (suppository preparations)
- asthma (inhaled preparations)
potential local adverse effects with long term administration of topical GC
skin atrophy, striae, rosacea, acne, purpura
duration of action of Aldosterone
very short (1-2h)
duration of action of fludrocortisone
short (8-12h)
what are aldosterone and fludrocortisone?
mineralocorticoids
which Mineralocorticoid has the highest Naᶧ retaining activity?
aldosterone-500
SE of mineralcorticoids
"CHER" Cardiac remodelling -->HF Hypertension Electrolyte abnormalities salt and fluid Retention
types of corticosteroid antagonists
receptor antagonists and synthesis inhibitors
what are spironolactone and eplerenone?
MC receptor antagonists
what is mifepristone?
GC receptor antagonit
how are the Corticosteroid receptor antagonists taken?
oral
why does spironolactone cause antiandrogenic effects?
it’s a weak antagonist of androgen receptor
indications of spironolactone
hyperaldosteronism
hypokalemia (caused by K wasting diuretics)
CHF
As Antiandrogenic (in PCOS)
