A.10- progestins and antiprogestins

Question 1

function of progestin (ovarian hormone)

Answer 1

1. induce secretory changes in the endometrium
2. breast proliferation
3. maintenance of pregnancy
4. metabolic effects- stimulate fat deposition

Question 2

what is the difference between biologic source progesterone and synthetic progesterone?

Answer 2

synthetic has an improved bioavailability

Question 3

list the progestins

Answer 3

1. progesterone
2. pregnans: medroxyprogesterone, drospirenone, cyproterone acetate
3. estrans: norethisterone
4. gonans: norgestrel, desogestrel

Question 4

indications of progestins

Answer 4

hormone replacement therapy
contraceptives
infertility treatment
prevent estrogen-induced endometrial cancer
maintain pregnancy (reproductive technology methods)

Question 5

SE of progestins

Answer 5

HDL ↓  LDL ↑
hypertension
weight gain
reversible decrease of bone density
↑ risk for breast cancer

Question 6

give 2 antiprogestins

Answer 6

Mifepristone

Ulipristal acetate

Question 7

what is mifepristone?

Answer 7

progestin and GC receptor antagonist

Question 8

how are anti-progestins given?

Answer 8

oral

Question 9

what is the indication for mifepristone?

Answer 9

medical abortion (in combination with Prostaglandin-E analogue MISOPROSTOL)- up to 49 days from last menstrual period

Question 10

Mifepristone SE

Answer 10

Gi disturbances, vaginal bleeding. atypical infection

Question 11

what is Ulipristal acetate?

Answer 11

an SPRM- selective progestin receptor modulator

Question 12

what is Ulipristal acetate used for?

Answer 12

emergency birth pill

myoma growth suppression