A2- DNA and anticancer drugs Flashcards

1
Q

Why is DNA acidic?

A

phosphate groups have P-O-H which can donate H+ (and form P–O-)

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2
Q

How many H bonds form between A and T?

A

2

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3
Q

How many H bonds form between C and G?

A

3

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4
Q

What do H bonds form between?

A

a H sandwiched between O or N

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5
Q

What 2 groups react (and on which molecules) to form phosphodiester bonds?

A

OH on Phosphate and OH on sugar

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6
Q

What sugar is found in DNA?

A

deoxyribose

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7
Q

Draw cisplatin…

A

H3N Cl
Pt
H3N Cl

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8
Q

How does cisplatin work?

A
  • N on adjacent Guanines forms coordinate bond with Pt, replacing H2O and Cl ligands
  • prevents DNA replication
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9
Q

Where does cisplatin bond to DNA?

A

2 adjacent G bases

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10
Q

How does cisplatin bond to DNA?

A
  • N atom in G bases has lone pair that it donates to Pt
  • forming a dative covalent bond
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11
Q

What displaces the Cl in cisplatin?

A

H2O

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12
Q

What displaces H2O ligands on cisplatin? What type of reaction is this?

A

N on Guanine bases
Ligand-substitution

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13
Q

What process does cisplatin prevent?

A

DNA replication

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14
Q

After cisplatin enters a cell, one of the chloride ligands is replaced by a water molecule to form a complex ion
Give the equation for this reaction.

A

[Pt(NH3)2Cl2] + H2O –> [Pt(NH3)2(H2O)Cl]+ + Cl-

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