9- Mucinoses Flashcards
What are the primary dermal mucins
Heparin
Chondroitin sulfate
Chronic and progressive disease that have multiple waxy dome shaped or flat-topped papules that may coalesce into plaques or become linear
Dorsal hands, face, elbows, extensor extremities
No mucosal lesions
Woody sclerosis, reduced range of motion
Scleromyxedema
Scleromyxedema sign that occurs at the proximal interphalangeal joint, induration surrounding a centrally depressed area
Doughnut sign
Most common visceral disease associated with scleromyxedema
Gastrointestinal
Treatment for scleromyxedema
Immunosuppressive agents -referred to oncologist
Poor prognosis
Stiffening and hardening of the subcutaneous tissues-as if infiltrated with paraffin
Scleredema
Types of Scleredema
Nondiabetic- after infection (streptococcal)
Diabetes associated- long lasting induration of the upper back
Inflammatory plaques with alopecia
Hypopigmented or erythematous and scaly or eczematous
Mostly on face, neck and scalp
Follicular mucinosis (alopecia mucinosa)
Widespread lesions of alopecia mucinosa in an older patient may lead to the development of
Cutaneous T cell lymphoma at presentation or progress to lymphoma within 5 years
Treatment of alopecia mucinosa
Spontaneous resolution-children
Topical corticosteroids
Hydroxychloroquine-first line systemic therapy
Cysts that occur most frequently on the dorsal or lateral terminal digits in hands or toes
Solitary opalescent or skin colored cysts
Osteoarthritis often present in the adjacent DIP joint
Myxoid cyst
Treatment of myxoid cyst
Repeated puncture technique for cysts beneath the proximal nailfold
Erythematous plaques or reticulated patches in the midline of the chest and back usually after intense sun exposure
May also occur with OCP, menses and pregnancy
Reticular erythematous mucinosis
Treatment of reticular erythematous mucinosis
Antimalarials
