15- Deep Mycoses Flashcards
Flulike illness
Lung changes on CXR- hilar adenopathy, infiltrate
Generalized maculopapular eruption
Pulmo sx subside within a few weeks
Erythema nodosum over shins then disappear after 3 weeks
Coccidiodomycosis (primary pulmonary)
Treatment for coccidiomycosis
Fluconazole 400-800mg/day
Itraconazole 200mg TID
X 12-18 months
Inhalation of airborne spores
Asymptomatic or limited lung disease
Immunocompromised/ systemic steroids
Ulcerations/ granulomas of the oronasopharynx
Histoplasmosis
Painless, slightly pruritic dome shaped nodular granulomas
Erythema nodosum
Organism found in bat and bird feces
African histoplasmosis
Treatment of choice for histoplasmosis
Amphotericin B
Begins as a pulmonary infection and remains localized to the lung in 90% of cases
10%- disseminate to CNS and skin
Immunocompromised
Molluscum contagiosum like lesions-50% of px with HIV and disseminated
Cryptococcosis
Most common cause of mycotic meningitis
Cryptococcosis
4th leading cause of opportunistic infection and 2nd most common fungal opportunist
Cryptococcosis
Treatment of cryptococcosis
Amphotericin B IV + oral fluconazole - seriously ill
Fluconazole 400-600mg/day x 8-10 weeks- less severely ill non -AIDS
Result from dissemination from a primary pulmonary focus
Multiple Verrucous, granulomatous lesions with thick crusts, warty vegetations on exposed skin
-thick dirty brown or gray crusts
Blastomycosis (North American)
Treatment of choice for North
American blastomycosis
Itraconazole 200-400mg/day x 6 months
Blastomycosis with mucocutaneous involvement
Armadillos may harbor the disease
South American (Paracoccidiodomycosis)
Treatment for south American blastomycosis
Itraconazole 200mg/day x 12 months
Usually from direct inoculation by a thorn, catβs claw
Small nodule that disappear before onset of other lesions
After few weeks- painless firm nodules along draining lymphatics
Sporotrichosis
Treatment of sporotrichosis
Itraconazole 200mg/day x 2-4 weeks