9. MI and angina

Question 1

What is the potent vasodilator produced from ATP in low O2?

Answer 1

Adenosine

Question 2

What are other vasodilators?

Answer 2

K+
bradykinin
H+

Question 3

What are the symptoms of MI?

Answer 3

Crushing chest pain, radiating down left arm
Unrelated to exercise
ECG changes
Biochemical markers

Question 4

What are the biochemical markers of MI and what is the problem with this method of diagnosis?

Answer 4

Troponins T and I

Stay around for very long time so cannot detect re-infarction

Question 5

What are the short term treatments for MI?

Answer 5

Oxygen if hypoxic
Diamorphine
Aspirin
GTN

Question 6

Long term treatments of MI?

Answer 6

aspirin/warfarin
Beta blockers
ACE inhibitors
Statins

Question 7

Symptoms of stable angina?

Answer 7

Pain beneath upper sternum, left arm, shoulder, neck and face

Question 8

Diagnosis of stable angina?

Answer 8

Increased HR and BP during attack
Stress test on treadmill
Pharmacological stress test - adenosine
Angiography
Nuclear imaging

Question 9

Angina treatments

Answer 9

vasodilators - NO and Ca channel blockers
Beta blockers
Surgical intervention

Question 10

What do drug eluting stents do?

Answer 10

prevent hyperplasia around stent

Question 11

Name two drugs used in drug eluting stents

Answer 11

Paclitaxel

Sirolimus

Question 12

Symptoms of unstable angina?

Answer 12

Heavy crushing pain for 10-20 minutes in neck, jaw, arm

Question 13

What is angina pain relieved by?

Answer 13

GTN