7. Blood disorders Flashcards
1
Q
Why does angiogenesis occur?
A
trauma embolism neoplasia diabetes just growth regeneration of endometrium after menstruation
2
Q
What does hypoxia stimulate? 2
A
EPO synthesis
Expression of genes for pro-angiogenic factors
3
Q
How is VEGF expressed?
A
VHLp not oxidised
HIF-α & -β binding the dimer is translocated to the nucleus
binds to the enhancer region of the VEGF gene
4
Q
What is the immediate stimulus for arteriogenesis?
A
mechanical - increased shear stress on the endothelial lining
5
Q
What is aplastic anaemia?
A
too few RBCs
6
Q
What is iron deficiency anaemia?
A
Hb defect
7
Q
What is pernicious anaemia?
A
B12 defect
8
Q
What is anaemia in leukaemia due to?
A
failure of erythropoiesis: malignant cells displace the erythroid precursors from their bone marrow niche
9
Q
Two important leukopenias and why?
A
- neutropenia - can lead to infection susceptibility
2. thrombocytopenia - leads to bleeding
