5. haematopoiesis Flashcards
what does the embryo split into?
Yolk/vitelline sac
embryo proper
what do stromal cells do?
provide support functions for other haematopoietic cells
In which part of the spongy bone is the bone marrow located?
trabaculae
why is there a reduction in telomere length during serial transplantation of HSCs?
HSCs have undergone more cell devision for reconstitution of haematopoietic lineages
how did McCulloch and Till show that all blood cell types could be derived from single BM cells?
radiated cells to cause chromosome markers, all descendants or marked cell would have the same marker
what antigen does the HSC express?
CD34
what are the two HSC niches?
- endosteum - boundary between solid bone and marrow
2. perivascular region - around vascular sinusoids
What is thought to be the differences between HSCs in the two niches?
endosteum - long term, slow division
perivascular region - more active division
How can a niche act on a stem cell? 3
- direct contact
- soluble factors
- intermediate cell
Name two cell specific growth factors and their cell types?
GM-CSF - granulocyte/monocyte
EPO - erythrocytes
Name a growth factor with a broader activity?
IL 3
What stimulates thrombopoiesis?
thrombopoietin
