9. Gastrointestinal Drugs Flashcards
What are the 4 common medical conditions that affect the gastrointestinal track?
- Gastric/Peptic Ulcers
- Excessive hydrochloric acid secretion
- Helicobacter pylori infection
- NSAID toxicity
- Inadequate mucosal defense against gastric acid
- Gastrointestinal Reflux Disease (GERD)
- Excessive hydrochloric acid secretion
- Diarrhea
- Constipation
What are the gastrointestinal therapy?
Excessive HCl Secretion Therapies
- Proton Pump Inhibitors (PPIs)
- H2 Receptor Blockers
- Antacids
What are the proton pump inhibitors drugs?
Esomeprazole [Nexium] “MOST COMMON”
Omeprazole [Prilosec]
Lansoprazole [Prevacid]
Pantoprazole [Protonix]
The mechanism of action of Esomeprazole is to Irreversibly inhibits gastric parietal cell ______, thereby inhibiting gastric acid secretion.
H+-K+-ATPase.
decreases K+ from going in and H+ from going out.
What are some serious adverse effects of taking Esomeprazole [Nexium]?
Stevens-Johnson Syndrom and toxic epidermal necrolysis
Which drugs do Esomeprazole cause absorption impaired by elevated pH?
Azole Antifunglas and Certain Antiviral Agents
What can Azole Antifungals do to Esomeprazole?
some azoles inhibit metabolism of proton pump inhibitors.
What is the drug interactions of CAIs with Esomeprazole?
Exacerbation of Hypomagnesemia
What is H2 Receptor Blockers?
It’s one of the excessive HCI Secretion Therapies drugs. Proton Pump inhibitors being the first one.
What are the H2 Receptor Blockers?
Cimetidine [Tagamet®] “MOST COMMON”
Ranitidine [Zantac®]
Famotidine [Pepcid®]
Nizatidine [Axid®]
Which gastrointestinal therapy is an indication for H. pylori infection?
Esomeprazole
Which gastrointestinal therapy is an indication for Dyspepsia?
Cimetidine
Which gastrointestinal therapy is an indication for GERD, Peptic Ulcer and Dyspepsia (indigestion or heartburn)?
Cimetidine
Which is the most common H2 blockers in gastrointestinal therapy?
Cimetidine
What is the Mechanism of Action of Cimetidine?
Selective antagonism of gastric parietal cell H2 (histamine) receptors