2. Neuromodulators Flashcards
What is the most common drug we use to treat ADHD and Narcolepsy?
Amphetamine [Adderall]. 5-40mg/day
What is the mechanism of action of Amphetamine?
It stimulates CNS through a sympathomimetic mechanism involving the enhanced release and reduced reuptake of norepinephrine and dopamine.
What are the different neuromodulator drug classes?
Psychomotor Stimulants Antidepressants Antipsychotics/Neuroleptics Neurodegenerative Therapies Anxiolytics & Hypnotics
What are the different neuromodulator drug classes?
Psychomotor Stimulants Antidepressants Antipsychotics/Neuroleptics Neurodegenerative Therapies Anxiolytics & Hypnotics
What happens if you give a patient opthalmic beta blockers & alpha 2 agonists in the presence of Amphetamine?
Hypertensive crisis. DO NOT do this.
What happens if you give a patient carbonic anhydrase inhibitors in the presence of Amphetamine?
renal excretion decreased in alkaline urine
What happens if you give a patient NSAIDs or Decongestants in the presence of Amphetamine?
Additive effect. NSAIDs is a caffeine base drugs.
Why is Amphetamine contraindicated with glaucoma patients?
Normally glaucoma is treated with sympathetic activity drugs (beta blockers and alpha 2 agonists) but Amphetamine is the opposite.
Why is Amphetamine contraindicated with glaucoma patients?
Normally glaucoma is treated with a drug (beta blockers and alpha 2 agonists) but Amphetamine is the opposite.
The different classes of antidepressant drugs.
- Selective serotonin reuptake inhibitor (SSRIs),
- Selevtive serotonin/norepinephrine reuptake inhibitor (SNRIs)
- Tricyclic antidepressant (TCADs)
- Atypical
- MAOIs
The most common SSRI antidepressant is?
Escitalopram [Lexapro]
The most common SSRI antidepressant is?
Escitalopram [Lexapro]
What is the indicator for Escitalopram?
major depressive disorder and generalized anxiety disorder
10-20mg qd
Your patient comes in with a subconjunctival hemorrhage, which combination of drugs give you that?
Escitalopram with NSAIDs and Omega 3 FA Or Duloxetine with NSAIDs and Omega 3 FA.
What is the effect of Escitalopram (SSRI) or Duloxetine (SNRI) on Beta blockers metabolism?
it will reduce it, which increases beta blockers concentration in the blood. Beware of glaucoma patients who are taking this.
Which SNRI drug is the the most commonly prescribed?
Duloxetine [Cymbalta]
What is the indication for Duloxetine (SNRI)?
Depression, anxiety, neuropathic pain (DM), Fibromyalgia
Dosing: 60mg qd
What effect does Opiods give in the presence of Duloxetine?
it’s an additive
Which antidepressant drug can cause angle closure glaucoma and bleeding risk?
Duloxetine (SNRI) because this drug is an stimulant for catecholamines, which naturally will produce a dilation.
The different classes of antidepressant drugs.
- Selective serotonin reuptake inhibitor (SSRIs),
- Selevtive serotonin/norepinephrine reuptake inhibitor (SNRIs)
- Tricyclic antidepressant (TCADs)
- Atypical
- MAOIs
Which drug is the most commonly prescribed Tricyclic antidepressants?
Imipramine [Tofranil]
Which drug is the most commonly prescribed Atypical antidepressants?
Trazadone [Desyrel]
What is the indication for taking Trazodone (atypical antidepressant)
Major depressive disorder (50-100mg bid - tid)
Insomnia (25-50mg qhs)