5. Erection dysfunction

Question 1

Which class of drug is the first ling therapy for men with erectile dysfunction (ED)?

Answer 1

Oral phosphodiesterase inhibitors

Question 2

What are the difference ED drugs?

Answer 2

1. Sildenafil [Viagra]
2. Tadalafil [Cialis]
3. Vardenafil [Staxyn, Levitra]
4. Yohimbine [Yocon]
5. Alprostadil [Caverject, Edex, Muse]

Question 3

What are the ED drug classes?

Answer 3

1. Phosphodiesterase inhibitors
2. Alpha-2 Antagonists
3. Prostaglandin-E1 Analogs

Question 4

What is Sildenafil [Viagra] uses for?

Answer 4

Erectile Dysfunction (Viagra®)
Pulmonary Arterial Hypertension (Revatio®)

Question 5

What is the mechanism of action for sildenafil citrate [Viagra]?

Answer 5

PDE-5 Inhibitor; sustains the vasodilatory effects of nitric oxide-dependent synthesis of cGMP

Question 6

What does vascular nitric oxide inhibits and activates when using Sildenafil?

Answer 6

INHIBITS:
LDL oxidation, platelet aggregation, monocyte adhesion, smooth muscle cell proliferation and superoxide radical elaboration
ACTIVATES: vasodilation

Question 7

What is the drug interactions of Azole, Antifunglas, Erythromycins and cyclosporine in the presence of Sildenafil Citrate [Viagra]?

Answer 7

Reduced metabolism

Question 8

What is the drug interactions of Alpha-Blockers, Beta-Blockers in the presence of Sildenafil Citrate [Viagra]?

Answer 8

Additive