11. Osteoporosis

Question 1

What are the Iatrogenic causes of Osteoporosis?

Answer 1

steroids, some anti-epileptic agents, anticoagulents, PPI’s thiazolidinediones and lithium.

Question 2

Which therapy is espeically useful in patients with prior fractures?

Answer 2

Bisphosphonate

Question 3

What is the drug use for Osteoporosis?

Answer 3

Alendronate [Fosamax]

Question 4

What is the mechanism of actions of Alendronate?

Answer 4

Having a strong affinity for Ca2+, these drugs accumulate in bone where, upon ingestion by osteoclasts, they inhibit the HMG-CoA reductase pathway and leads to cell death, reducing bone resorption and turnover (bisphosphonate)

Question 5

What is the common adverse effect when taking Alendronate?

Answer 5

Photosensitivity

Question 6

What are some serious adverse effects when taking Alendronate?

Answer 6

Hypersensitivity: Angioedema (allergic reaction)
Ocular: Uveitis, scleritis

Question 7

What happens when you take NSAIDs and Alendronate together?

Answer 7

Adding to more gastrointestinal tract irritation.

Question 8

T/F People who are taking Alendronates are at equal risk of developing uveitis and scleritis, old or new patients.

Answer 8

False. only new patients are at higher risk for developing these ocular inflammations.