3. Analgesics Flashcards
Where do we see prostaglandins in the body? Locally or throughout the body?
Locally
____ is thought to sensitize nerve endings to the action of bradykinin (seen in ACE inhibitors), histamine, and other chemical mediators.
PGE2
What are the common adverse side effects of Acetaminophen?
Nausea, rash and headache
what other serious side effects can Acetaminophen produce?
Acute hepatotoxicity (>4g/tid) Acute renal tubular necrosis, chronic analgesic nephropathy.
What is the drug interactions of Lidocaine Topical in the presence of Acetaminophen?
Additive methemoglobinemia. This drug increases the oxygen binding affinity. Therefore, oxygen is refuse to leaves, which then leads to hypoxia.
What is the mechanism of action of Ibuprofen?
inhibits COX, reducing PG (inflammation) and TXA2 (platelet aggregation) synthesis.
What is the drug interactions of ASA NSAIDs and Acetaminophen in the presence of Ibuprofen?
Additive hemorrhagic risk
What is the drug interactions of Cyclosporine and Acetaminophen in the presence of Ibuprofen?
Additive nephrotoxicity
What is the indications for Celecoxib?
Arthritis, Ankylosing Spondylitis, Dysmenorrhea, Acute pain
Dosing [50-400mg]… 200mg qd-bid
the mechanism of actions of Celecoxib is selectively inhibits ____ and reduces ____ synthesis.
COX-2, PG
Which NSAIDs has Black Box Warnings?
CV: Stroke, CHF, MI
GI: Bleed, ulceration/perforation
What is the drug interactions of NSAIDs (esp Ketorolac), Corticosteroids in the presence of Celecoxib?
Hemorrhage
What is the drug interactions of Azoles in the presence of Celecoxib?
impaired metabolism
T/F Celecoxib is contraindicated in sulfonamide allergies.
True. Same as with Furosemide.
T/F Celecoxib is contraindicated in sulfonamide allergies.
True. Same as with Furosemide.