4. Respiratory Therapies Flashcards
Which is the most prescribed respiratory therapy drug?
Montelukast [Singulair]
Is Montelukast an inhale or tablet form?
tablet.
dosing [10mg].. 1 tab qd
Which class of respiratory therapy drug is Montelukast?
Leukotriene inhibitors
Which endogenous ligands do Montelukast block in their leudotriene receptors?
LTC4, LTD4, and LTE4, released by mast cells and eosinophils
What are the different respiratory therapy drug classes?
Leukotriene inhibitors
Beta-2 Agonists
Steroidal Anti-inflammatories
What is the indication for Montelukast?
Asthma
Bronchospasm
Allergic rhinitis
Is there any drug interactions with Montelukast and ocular therapeutics?
None
What is the indications for Albuterol?
Asthma, bronchospasm, COPD
T/F Albuterol is a long acting beta 2 agonist.
False. It’s short acting beta 2 agonist which provide quick relieves, relaxation in smooth muscle airway.
What is Fluticasone use for?
It’s a respiratory therapy. It has steroidal anti-inflammatory properties.
What is the mechanism of action of Fluticasone?
It acts through classic steroid pathway inhibiting arachidonic acid-based eicosanoid production
What is Salmeterol [Advair Diskus] use for?
It’s a respiratory therapy.
It causes bronchodilation, for asthma/COPD Maintenance
What is the mechanism of action of Salmeterol?
It’s a chemical analog of Albuterol having a lipophilic side chain that enhances duration of action; like Albuterol, this β2 Agonist produces relaxation of airway smooth muscle
What is the drug interaction of Salmeterol with B-Blockers?
Additive
What is the drug interaction of Salmeterol with Clyclosporine, Azole antifungals?
Impaired Metabolism
What is the drug interaction of Salmeterol with Macrolides, Amphotericins, CAIs and Steroids?
Hypokalemia
What is the drug interactions of Salmeterol with Macrolides and sympathomimetics?
QT Prolongation
What are the different respiratory therapies?
Montelukast [Singulair®]
Albuterol [ProAir HFA®]
Fluticasone/Salmeterol [Advair Diskus®]
Mometasone [Nasonex®]
What is Mometasone use for?
It’s a respiratory therapy.
It uses for allergic rhinitis, nasal polyp therapy
[50 microgram/spray] - 2 sprays qd-bid
What is the mechanism of action of mometasone?
Inhibits multiple inflammatory cytokines; produces multiple glucocorticoid and mineralocorticoid effects
What are the drug interactions of Mometasone?
None
Which respiratory therapies doesn’t involve any drug interactions?
Montelukast (None involving ocular therapeutics)
Mmetasone (None)
What are the contraindications/cautions when taking Mometasone?
- Nasal septal ulcer, recurrent epistaxis
- TB infection
- Ocular HSV infection, glaucoma, cataracts, vision changes
