9 EBM Flashcards

1
Q

Busy clinicians have an obligation to understand primary (original) research in order to maintain relevant, up to date practice.
Need to utilize information management to find:

A

Clinically applicable primary sources and appraise them critically.

Appropriate secondary sources that summarize the relevant literature and deliver a useful, actionable bottom line.

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2
Q

Clinicians must also be able to sift through which articles have been evaluated with sufficient academic rigor.

Considerations?

A

Peer-reviewed?

Academic journal vs. “throwaway”

Sponsorship?
(pharmaceutical company, etc.)

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3
Q

The revised and improved definition of evidence-based medicine is a systematic approach to clinical problem solving which allows the integration of the best available research evidence with clinical expertise and patient values

A

New Definition of EBM

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4
Q

New Definition of EBM

A

The revised and improved definition of evidence-based medicine is a systematic approach to clinical problem solving which allows the integration of the best available research evidence with clinical expertise and patient values

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5
Q

Purpose of EBM?

A
  • Enable clinicians to provide more accurate/up-to-date and timely information to patient questions
  • Medicine is constantly evolving
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6
Q
  1. Optimal clinical decision making requires awareness of the best available evidence, which ideally will come from systematic summaries of that evidence.
  2. EBM provides guidance to decide whether evidence is more or less trustworthy—that is, how confident can we be of the properties of diagnostic test, or our patient’s prognosis, or of the impact of our therapeutic options?
  3. Evidence alone is never sufficient to make a clinical decision.
A

Three Fundamental Principles of EBM

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7
Q

Three Fundamental Principles of EBM

A
  1. Optimal clinical decision making requires awareness of the best available evidence, which ideally will come from systematic summaries of that evidence.
  2. EBM provides guidance to decide whether evidence is more or less trustworthy—that is, how confident can we be of the properties of diagnostic test, or our patient’s prognosis, or of the impact of our therapeutic options?
  3. Evidence alone is never sufficient to make a clinical
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8
Q

Used to rate our confidence in the estimates of the effects of health care interventions

A

GRADE (Grading of Recommendations Assessment, Development, and Evaluation)

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9
Q

Simplified process for EBM implementation

A
1 Assess
2 Ask
3 Acquire
4 Appraise
5 Apply
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10
Q

In this step, the clinician identifies the need to gather information regarding a patient-centered problem

A

1 Assess

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11
Q
Patient, Problem, or Population
Intervention
Comparison or Control
Outcome
Type of Question
Type of Study
A

2 Ask

PICOTT

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12
Q

Two types of questions:

A

Background

Foreground

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13
Q

PICOTT?

A

Patient/Problem/Population

Intervention

Comparison/Control

Outcome

Type of study

Type of question

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14
Q

Ask for general knowledge about an illness, disease, condition, process or thing.
These types of questions typically ask who, what, where, when, how & why about things like a disorder, test, or treatment

A

Background-

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15
Q

Ask for specific knowledge to inform clinical decisions.
Typically concern a specific patient or particular population.
Tend to be more specific and complex compared to background questions.
Best answered by consulting medical databases

A

Foreground

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16
Q

The process by which the clinician (researcher) selects the appropriate resource(s) to conduct a search to answer the clinical question.

A

3 Acquire

17
Q

Prospective > retrospective studies…

A

y’all knew that

18
Q

Evaluate how recently the summary was updated or revised
Not all topics are covered by filtered information resources
Meta-analyses, Cochrane Database of Systematic Reviews.
Clinical Practice Guidelines

A

Filtered Resources

19
Q

Better known as “primary literature”
It’s up to YOU to assess quality, validity and applicability to your patient
Requires time and experience

A

Unfiltered Resources

20
Q

To learn about a new topic or refresh knowledge
Provide a comprehensive overview of a disease, condition, or concept
Usually in a textbooks, Medline, Medscape, UpToDate

A

Background Resources

21
Q

We have now identified current information which can answer our clinical question.

The next step is to read the article and evaluate the study.

A

4 Appraise

22
Q

In Step 4, Appraise, you can employ what mnemonic device/

A
Patient/prob/pop
Intervention
Comparison/control
Outcome
Numbers of subjects
Statistics
23
Q

Is this article from a peer-reviewed journal?
Is the location of the study similar to mine?
Is the study sponsored by an organization that may influence it?
Will this information impact my patients?
Is the problem addressed in the study common to my practice?
Is the intervention or test studied feasible/available to me?
Will this change my practice?

A

4 Appraise

24
Q
Sensationalized Headlines
Misinterpreted Results
Conflict of Interests
Correlation vs. Causation
Speculative Language
Small Sample Size
Unrepresentative Samples
No Control Group
No Blinding
“Cherry-Picked” Results
Results That Cannot be Replicated
Journals and Citations
A

Bad Science

4 Appraise

25
Q

The evidence alone is never enough, and the last step of the EBP process arguably requires the most skill.
This step requires the synthesis of the results of your research with your clinical expertise and the patient’s unique values and circumstances to reach a clinical decision

A

5 Apply

26
Q

Knowledge and Skills for Optimal EBM

A

Check slide 36 (lecture 9)

27
Q

Formulate an answerable clinical research question in accordance with the principles of evidence-based practice

A

PICOTT

28
Q

Discusses how to approach and interpret the scholarly literature in accordance with the principles of evidence-based practice

A

PICONS