9-10 weeks // Cellular Radiobiology

Question 1

“For the cell to die after radiation exposure its target molecule must be inactivated.”

Answer 1

Target Theory

Question 2

This occurs when radiation interaction occurs with the target.

Answer 2

Hit

Question 3

Two Models of Cell Survival

Answer 3

Single Target, Single Hit Model
and
Multi Target, Single Hit Model

Question 4

In two models of cell survival, this applies to biologic targets such as enzymes, viruses and bacteria.

Answer 4

Single Target, Single Hit Model

Question 5

This is when the radiation dose reaches a level sufficient to kill 63% of the cells and 37% of survivial.

Answer 5

D37

Question 6

Low D37 is highly ___.

Answer 6

Low D37 is highly radiosensitive.

Question 7

High D37 is highly ___.

Answer 7

High D37 is highly radioresistant.

Question 8

In two models of cell survival, this applies to more complicated biologic targets and it represents a threshold.

Answer 8

Multi Target, Single Hit Model

Question 9

This is constantly related to radiosensitivity of the cell.

Answer 9

Do

Question 10

Small Do indicates ___ cell.

Answer 10

Small Do indicates radiosensitive cell.

Question 11

Larger Do indicates ___ cell.

Answer 11

Larger Do indicates radioresistant cell.

Question 12

This is related to the cell ability to recover from sublethal damage. This is used to measure the capacity to accumulate sublethal damage and the ability to recover from the damage.

Answer 12

Dq

Question 13

In LET, cell survival kinetics follows the single target, single hit model.

Answer 13

At very high LET

Question 14

In LET, cell survival kinetics follows the multi target, single hit model.

Answer 14

At low LET