7-8 weeks // Molecular Radiobiology Flashcards
If the initial ionizing event occurs on the target molecule.
Direct Effects
If the initial ionizing event occurs on a distant, noncritical molecule and the energy is transferred to the target molecule.
Indirect Effects
In irradiation of macromolecules, it occurs outside the body or outside the cell.
In Vitro
In irradiation of macromolecules, it occurs within the living cell.
In Vivo
Three Types of Irradiation of Macromolecules in Vitro
Main Chan Scission, Cross-linking and Point Lesion
In three types of irradiation of macromolecules in vitro, this is the breakage of the backbone of the long-chain macromolecule.
Main Chain Scission
It determines the degree of main chain scission.
Measurement of Viscosity
In three types of irradiation of macromolecules in vitro, it is the process of side spurs created by irradiation and attached to a neighboring macromolecules or to another segment of the same molecule.
Cross Linking
Its effect increases the viscosity of the macromolecular solution.
Cross Linking
In three types of irradiation of macromolecules in vitro, it is any change that results in the impairment or loss of function at the point of a single chemical bond.
Point Lesions
In free radicals, it is the poisonous to the cell and therefore acts as a toxic agent.
Hydrogen Peroxide (H202)
In free radicals, it is the principal damaging product of radiolysis of water.
Hydroperoxyl Radical (HO*2)