8b DNA damage Flashcards
1
Q
what is alkylation of DNA?
A
addition of ethyl or methyl group
2
Q
how does alkylation cause DNA damage?
A
addition of the alkyl to the bases functional group making them more bulkier
3
Q
how do UV radiation cause DNA damage?
A
they catalyse bond formation.
free radicals can be formed from the DNA and cause damage
4
Q
what are two consequences of DNA damage?
A
block in replication
mutagenic
5
Q
what type of DNA damage occurs from UV light?
A
thymine dimers
