8.2 NSAIDs Flashcards
prosatnoids include:
prostaglandins
prostcyclin
thromboxanes
in what was do prostanoids allow for fine local control?
produced locally on demnd
short half lives
different enzymes
which protanoids have opposing vascular effects?
TXA2 and PGI2
COX 1 homeostatic functions
GI protection
platelet aggregation
vascular resistance
COX 2 homeostatic functions
inhibit platelet aggreaggtion
renal function
COX 1 pathological functions
chronic inflammation
chronic pain
COX 2 pathological functions
chronic inflammation
chronic pain
blood vessel permeability
explain how NSAIDs have an analgesic effect
blocks PGE2 to recue peripheral pain fibre sensitiv ity
when do NSAIDs reach their full analgesic affect?
efficacious after 1 dose, but full after several days
explain how NSAIDs have an anti-inflammatory effect
decrease prostaglandin synthesis at site of injury so less vasodilation and swelling
explain how NSAIDs have an antipyretic effect
inhibition of hypothalamic cox-2 so less prostaglandins produced, decreases temp
name a more cox1 selective drug, and a more cox-2 selective
1- aspirin low dose
2- etoricoxib
GI contraindications for NSAIDs
elderly
smoker
prolonged use
alcoohl
peptic ulcer
H pylori
renal contraindications for NSAIDs
CKD, HF due to usual reliance on prostaglandins for vasodilation of afferent arteriole and renal perfusion
why can NSAIDs cause raised BP and sodium?
inhibit the natriuresis caused y prostaglandins
