4.2 PV & PG

Question 1

adverse drug event

Answer 1

injury occurs during treatment, not necessarily caused by drug itself

Question 2

type A ADR

Answer 2

predictable from known pharmacology of drug, high morbidity, low mortality

Question 3

type B ADR

Answer 3

idiosyncratic, bizarre, novel response cant be predicated from pharmacology, low morbidity, high mortality

Question 4

link PK to genetic variability

Answer 4

ADME

Question 5

link PD to genetic variability

Answer 5

receptors, ion channels, enzymes, DNA

Question 6

4P’s of pharmacogenetics

Answer 6

prediction+prevention
precise
personalised
participatory

Question 7

mechanism of action of warfarin

Answer 7

vit K antagonist so cant activate clotting factors nor recycle vit K, less clotting