2. PK & PD

Question 1

factors that affect CYP activity, and how they change it

Answer 1

age- reduce
hepatic disease- reduce
chronic alcohol- increase
cigarette smoking- increase

Question 2

which routes does clearance include?

Answer 2

metabolism and excretion

Question 3

consideration for antibiotics when on warfarin/morphine

Answer 3

antibiotics can disrupt gut bacteria, so other meds may not be eliminated as much, so dose may need adjusting to prevent levels getting too high

Question 4

equation linking t1/2, Vd, and CL

Answer 4

t1/2= 0.693xVd divide CL

Question 5

which factors could cause longer half life?

Answer 5

larger Vd
slower CL