8. Myeloid

Question 1

Acute myeloid leukemia

Answer 1

Definition
Infiltration of malignant myeloid cells in blood

Pathophysiology
Mutation inhibition of maturation of myeloid stem cell
Hereditary radiation chemical

Classification

Fab

Minimally differentiated aml myeloid lineage antigens
Aml without maturation myeloblast
Aml with maturation myely with promyelocyte
Acute promyelocytic leukemia hypergranular promyelocyte
Acute myelomonocytic leukemia mature myeloid mono
Acute monocytic leukemia a poor diff monoblast b diff promonocytes monocytes
Acute erythroleukemia erythroblasts
Acute megakaryocytic leukemia undifferentiated blasts

Clinical
Gum hypertrophy

Laboratory
Blood picture
Bone marrow
Cytochemistry
Noo Sudan pas nse acid phosphatase
Biochemical serum muramidase serum uric acid

Treatment
Anemia
Infection
Cytotoxic drugs
Bone marrow transplant
Prognosis poor most malignant 12-18 months

Question 2

Chronic myeloid leukemia

Answer 2

Definition
Pathophysiology
Clinical features
Laboratory findings
Treatment
Prognosis