3. Immunopathology Amyloidosis Flashcards
Amyloidosis
List
Physical and chemical characteristics Classification Pathogenesis Staining Morphology of organs Diagnosis Prognosis
Amyloidosis.
Define
Group of disease
Extracellular deposition of fibrillar insoluble proteinaceous substance called amyloid
Amylin starch
Amyloidosis
Physical and chemical characteristics
Fibril protein 95
Non fibrillar protein 5
Amyloidosis
Physical and chemical characteristics
Fibril protein
AL
immunoglobulin light chain lambda>kappa
AA
Protein derived from Saa serum amyloid association protein
OTHER
Transthyretin Abeta 2 myoglobulin Amyloid beta peptide Endocrine amyloid Amyloid prion Protein plasmas membrane glycoprotein
Amyloidosis
Physical and chemical characteristics
Non fibrillar protein
Amyloid ap component
Apolipoprotein e
Sulphated glucosaminoglycans
Other
Classification of amyloidosis
Systemic
Localised
Classification of amyloidosis
Systemic
Generalised amyloidosis Primary al Secondary/reactive aa Haemodialysis associated ab2m Heredofamilial Hereditary polyneuropathies attr Familial Mediterranean fever aa Rare hereditary forms
Classification of amyloidosis
Localised amyloidosis
Senile cardiac attr
Senile cerebral ab aprp
Endocrine
Tumor forming al
Pathogenesis of amyloidosis
Pool of excess precursor protein
Reversible misfolding and aggregation
Non fibrillar components
Staining of amyloid
H and e pink hyaline homogeneous
Methyl violet crystal voilet metachromasia rose pink
Congo red pink red red green bifringence in polarizing light
Thioflavin s t uv florencence
Immunohistochemistry immunoreactivity positive
Organs amyloidosis
Kidney
Gross normal.enlarged terminally contracted cut pale waxy transparent
Micro deposit on basement membrane of glomerular capillaries
Lumen narrow
Distortion of capillary tuft
Amyloidosis of spleen
Sago cut surface pale waxy nodules
White pulp
Lardaceous map like lard spleenomegaly
Red pulp wall of arteries
