7. Transfusion Flashcards
1
Q
Immune thrombocytopenic Purpura
A
Define
Immunologic destruction of platelets
Normal or increased megakaryocytes in bone marrow
Pathogenesis
Acute
Self limit Children Recovery from viral diseases Immune complexes containing viral antigens Formation of ab. Against antigens Cross react with platelets
Chronic
Adult women child bearing age
Antiplatelet autoantibodies
Ig g in spleen
Clinical
Petichial haemorrhages
Easy bruising
Mucosal bleeding nasal gums hematuria menorrhagia
Chronic spleenomegaly hepatomegaly
Laboratory
Platelets 10k to 50k Blood film occasional platelets Marrow increase megakaryocytes Antiplatelet ig g ab on platelet surface Platelet survival less than hour
Treatment
Recover spontaneously
Corticosteroid
Immunosuppressive drugs
Splenectomy
2
Q
Transfusion reactions
A
Immunological
Haemolytic
Intravascular abo
Extravascular rh anamnestic reaction
Transfusion related acute lung injury
Other allergic reaction
Febrile anaphylaxis iga urticaria graft vs host disease
Non immune
Circulatory overload
Massive transfusion
Infection
Air embolism
Thrombophlebitis
Transfusion haemosiderosis
3
Q
Clotting cascade
A
12a 11 11a 9 9a(8 8a 7 7a) 10 (5 5a)10a prothrombin2 thrombin2a fibrinogen fibrin monomer polymer clot
