8 MHC Flashcards
what happens in innate immune system (summary)
microbe enters epithelial barriers, ingested by phagocytes and activates complement and NK cells
what is involved in the adaptive immunity response
- B lymphocytes form antibodies
- T lymphocytes form effector T cells
Studies with CONGENIC mice
mice rejects cells from each the other mouse genes are codominants – parents reject F1graft
if mate the two mice = F1 generation, still rejects cells from mother and father
backcrossing to get as similar as possible to what you started with
till do not reject
what are the main conclusions from backcrossing CONGENIC mice
- genes are codominant
- particular genetic region is responsible for rejection to transplanation
- genetic region not a single locus but group of loci in tandem array along chromosome
where is the gene conversion
between misaligned chromosomes during meiosis
separated chromosomes after meiosis
what causes crossovers
high allelic variation
what causes MHC gene divergence
ancestral MHC gene undergoes gene duplication and divergence
multiple MHC genes
what does every nucleated cell in the body have
MHC 1
when does MHC 1 differ
between different people
what are the HLA for MHC class 1
HLA-A
HLA-B
HLA-C
which is cellular immune response
MHC 1
what are the HLA for MHC 2
HLA-DR
HLA-DQ
HLA-DP
which is the humoral response
MHC 2
where is MHC 2 present
only in cells of the immune system
what is a promiscious protein
can fit the same peptide at different groove part
