Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Principles of Immunology > 5 Plasma Proteins > Flashcards

5 Plasma Proteins Flashcards

1
Q

examples of immune proteins

A

immunoglobins
complement proteins
lymphokines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

examples of haemostatic proteins

A

fibrinogen
coagulation factors
fibrinolytic factors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

examples of ECM proteins

A

fibronectin
vitronection
collagen fragments
MMPs and TIMPs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

examples of lipoproteins

A

high density
low
very low

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Origin of blood proteins

A

Liver
Lymphocytes
Fibroblasts and epithelial cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Liver blood proteins

A
  • Albumin
  • Heamostatic proteins (incl. fibrinogen)
  • Fibrinolytic proteins
  • Complement proteins
  • Binding proteins
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

lymphocyte blood proteins

A

Immunoglobulins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Fibroblasts and epithelial cells blood proteins

A

ECM proteins and proteases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

General actions of blood proteins

A
  1. Osmotic balance
  2. Buffering
  3. Transport
  4. Cellular uptake
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Osmotic balance

A

Colloid osmotic pressure of total blood protein = 25mmHg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what is osmotic balance essential for

A

Essential for maintenance of cell volume and interstitial fluid volume

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Buffering pH 7.4

A

Mostly anionic (-ve), due to abundance of albumin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

proteins importance in buffering

A

Proteins provide about 15% of buffering capacity of blood

Most of the rest is due to bicarbonate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Transport - Increases carrying capacity

A
  • Binding to a highly polar (water soluble) molecule can increase the blood concentrations of hormones, nutrients, metabolites, drugs etc.
  • Especially important for non-polar (lipophilic) molecules
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Transport - Reduces degradation and excretion rates

A
  • Free proteins are open to degradation by proteases

- Free lipophilic molecules and others may be excreted rapidly by kidneys

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

effect of binding to a particular protein

A

Binding to a large molecule give protection and extends the half life

17
Q

thyroid hormone binding globulin

A

TBG

18
Q

effect of free T1/2

A

lasts minutes in body

19
Q

effect of bound T1/2

A

last 7 days in body

20
Q

Cellular uptake

A

Some metabolites need a specific protein to facilitate uptake into cells

21
Q

Cellular uptake example

A

Iron (Fe3+) transported by Transferrin

Endocytosis (clathryn-coated pit) and recycling of transferrin

22
Q

what % of blood protein does albumin make up

A

50% of total blood protein (40-50 g/l)

23
Q

effect if albumin is highly polar

A

highly water soluble

24
Q

where is albumin made

A

Made and metabolised in liver

25
Q

where is albumin

A

60% is in blood, rest is in skin

26
Q

albumin functions

A
  • osmotic balance
  • pH buffering
  • binding
27
Q

what does albumin bind

A

almost anything (hormones, metabolites, minerals, drugs)

28
Q

albumin capacity

A

High capacity (due to size and abundance)

29
Q

albumin affinity

A

Low affinity, non-specific binding (Kd 10-4-10-6)

Principles of Immunology (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions