8. Haematology Flashcards
A neoplastic disorder of lymphoid tissue usually associated with t(14;18)?
Follicular lymphoma
Widespread activation of the clotting cascade resulting in the formation of clots throughout the small blood vessels?
Disseminated intravascular coagulation
A genetic blood disorder resulting in a rigid abnormally shaped red blood cell?
Sickle cell disease
Organ essential to the maintenance of normal levels of coagulation factors?
Liver
Chromosomal abnormality seen in CML?
Philadelphia chromosome
An example of an anti-platelet agent that is a P2Y12 inhibitor?
Clopidogrel
What is the most common heritable bleeding disorder?
Von Willebrand disease
Oral anticoagulant used to prevent thrombosis and thromboembolism?
Warfarin
Lineage associated with the production of erythrocytes?
Myeloid
A small molecule specifically designed to block the active site in the Bcr-Abl tyrosine kinase (the brand name)?
Gleevec
The process of mixing a patients plasma with aliquots of donor red cells to see if a reaction occurs?
Crossmatching
Increase in the number of red blood cells?
Polycythaemia
Small red spots (<3 mm) on the skin that do not blanch with pressure?
Petechiae
Neoplasm where the proliferation of abnormal haematopoietic stem cells leads to scarring of the marrow?
Myelofibrosis
A type of lymphoma characterised by the presence of Reed-Sternberg cells?
Hodgkin’s Lymphoma
Possible severe complication of intensive chemotherapy in acute leukaemia?
Neutropenic sepsis
Type of anaemia associated with atrophic gastritis?
Pernicious
The physiological developmental process that gives rise to the cellular components of blood?
Haemopoiesis
Tyrosine kinase inhibitor that is effective in CML?
Imatinib
Malignant clonal proliferation of plasma cells?
Myeloma
What is a common cause of subacute combined degeneration of the cord?
B12 deficiency
What is the major protein fraction identified in serum protein electrophoresis from normal patients?
Albumin
Type of anaemia commonly resulting in a microcytic hypochromic picture?
Iron deficiency
A type of anaemia associated with folic acid deficiency?
Megaloblastic
An X-linked recessive disorder resulting in factor VIII deficiency?
Haemophilia
