8. Haematology

Question 1

A neoplastic disorder of lymphoid tissue usually associated with t(14;18)?

Answer 1

Follicular lymphoma

Question 2

Widespread activation of the clotting cascade resulting in the formation of clots throughout the small blood vessels?

Answer 2

Disseminated intravascular coagulation

Question 3

A genetic blood disorder resulting in a rigid abnormally shaped red blood cell?

Answer 3

Sickle cell disease

Question 4

Organ essential to the maintenance of normal levels of coagulation factors?

Answer 4

Liver

Question 5

Chromosomal abnormality seen in CML?

Answer 5

Philadelphia chromosome

Question 6

An example of an anti-platelet agent that is a P2Y12 inhibitor?

Answer 6

Clopidogrel

Question 7

What is the most common heritable bleeding disorder?

Answer 7

Von Willebrand disease

Question 8

Oral anticoagulant used to prevent thrombosis and thromboembolism?

Answer 8

Warfarin

Question 9

Lineage associated with the production of erythrocytes?

Answer 9

Myeloid

Question 10

A small molecule specifically designed to block the active site in the Bcr-Abl tyrosine kinase (the brand name)?

Answer 10

Gleevec

Question 11

The process of mixing a patients plasma with aliquots of donor red cells to see if a reaction occurs?

Answer 11

Crossmatching

Question 12

Increase in the number of red blood cells?

Answer 12

Polycythaemia

Question 13

Small red spots (<3 mm) on the skin that do not blanch with pressure?

Answer 13

Petechiae

Question 14

Neoplasm where the proliferation of abnormal haematopoietic stem cells leads to scarring of the marrow?

Answer 14

Myelofibrosis

Question 15

A type of lymphoma characterised by the presence of Reed-Sternberg cells?

Answer 15

Hodgkin’s Lymphoma

Question 16

Possible severe complication of intensive chemotherapy in acute leukaemia?

Answer 16

Neutropenic sepsis

Question 17

Type of anaemia associated with atrophic gastritis?

Answer 17

Pernicious

Question 18

The physiological developmental process that gives rise to the cellular components of blood?

Answer 18

Haemopoiesis

Question 19

Tyrosine kinase inhibitor that is effective in CML?

Answer 19

Imatinib

Question 20

Malignant clonal proliferation of plasma cells?

Answer 20

Myeloma

Question 21

What is a common cause of subacute combined degeneration of the cord?

Answer 21

B12 deficiency

Question 22

What is the major protein fraction identified in serum protein electrophoresis from normal patients?

Answer 22

Albumin

Question 23

Type of anaemia commonly resulting in a microcytic hypochromic picture?

Answer 23

Iron deficiency

Question 24

A type of anaemia associated with folic acid deficiency?

Answer 24

Megaloblastic

Question 25

An X-linked recessive disorder resulting in factor VIII deficiency?

Answer 25

Haemophilia