8 Adrenergic Antagonists Flashcards

1
Q

**a1 block **

predicted effect?

A

vasodilation

relaxatino fo iris radial muscle

relaxation of genitourinary muscle

viscous salivation decreased

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2
Q

a2 block

predicted effect?

A

increased NE release - sympathomimetic

increased insulin secretion

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3
Q

predicted effects of an a1, a2 block

A

acts as an a1 block

has increased b effects(due to NE release from a2 block)

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4
Q

a1/a2 non-selective antagonists

use?

A

phenoxybenzamine -irreversible

phenotolamine - competitive antagonist

used in catecholamine-secreting tumor surgeries

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5
Q

a1AR blockers/antagonists

A

prazosin

erazosin

tamsulosin

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6
Q

uses for a1 blockers

A

primary hypertension

raynaud’s disease

relaxing urinary tract sm

voiding kidney stones

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7
Q

a1a selective a1AR blocker used for benign prost. hypertrophy

A

tamsulosin

more selective relaxant of uretrhal sphincter

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8
Q

adverse effects of a1AR blockers

A

postural hypotension

nasal congestion

dry mouth

delayed ejaculation, retrograde ejactulation

priapism - sustained painful erection

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9
Q

a2AR blocker

use?

A

yohimbine

used for orthostatic hypotension

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10
Q

yohimbine adverse effects

A

palpitation

diarrhea

dyspepsia

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11
Q

indications for b-blocker

A
  1. CV issues: angina, arrhythmias, systolic heart failue, primary hypertension
  2. hyperthyroidism
  3. migraine
  4. glaucoma
  5. tremors, stagefright
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12
Q

adverse effects of b-blockers

A
  1. reduced exercise capacity
  2. AV conduction block
  3. peripheral vasoconstriction(cold extremities)
  4. withdrawal b-supersensitivity
  5. exercise induced hyperkalemia/muscle weakness
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13
Q

nonselective b-blockers

1st gen

A

propanolol - highly lipid soluble

timolol - eye drops

block b1/b2

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14
Q

b1 selective blockers

A

atenolol - longer t12/

metoprolol - moderate lipid solubility

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15
Q

nonselective b-blockers w/vasodilator action

3rd generation

A

carvedilol - moderate lipid solulibitly, longer t1/2

labetalol - a1 blocker as well as b-blocker

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16
Q

acute vascular resistance in response to b-blockers is likely due to…

A

response to decreased HR/contractility

because b1-selective blockers have acute vascular resistance the same as b2-selective, the mechanism is likely NOT due to b2AR antagonism

17
Q

why do b-blockers reduce BP?

A

NOBODY KNOWS