27 lipo drugs Flashcards

1
Q

name the statins

A

lovastatin(prototype)

simvastatin, pravastatin

atorvastatin, rosuvastatin - more potent

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2
Q

mechanism of statin action

A

HMG-CoA reductase

rate-limiting step in cholesterol synthesis

also have ‘other’ effects: inflammation reduction, increased endothelial function

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3
Q

statin metabolism

A

CYP enzymes(all except pravastatin)

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4
Q

adverse effects of statins

A

hepatitis

rhabdomyolysis(extra protein can hurt kidney)

diabetes induction

teratogenic

polyneuropathy

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5
Q

clinically relavent bile acid binding resins

A

cholestyramine

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6
Q

cholestyramine mechanism

A

bind bile acid salts so they cant be reabsorbed

makes the liver utilize more cholesterol to make up for lost salts

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7
Q

adverse effects of cholestyramine

A

bile-acid binding resin

GI distress

adsorb vitamins/drugs/statins in stomach

can increase TG in hyper-TG

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8
Q

blocks cholesterol absorption

A

ezetimibe

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9
Q

effective drug for sitosterolemia(hyperabsorption of plant sterols)

A

ezetimibe

blocks cholesterol/plant sterol absorption

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10
Q

nicotinic acid mechanism

A

stops lipolysis

decreases ApoA-I catabolism

raises HDL

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11
Q

best hypolipidemic drug for raising HDL

A

niacin/nicotinic acid

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12
Q

best hypolipidemic drugs for lowering TG

A

fibrates - gemfibrozil, fenofibrate

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13
Q

best drugs for lowering LDL

A

statins

simva-statin

prava-statin

atorva-statin

rosuva-statin

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14
Q

familial hypertriglyceridemia effect on lipoproteins

A

high VLDL

low LPL activity

very high TG levels

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15
Q

familial combined hyperlipidemia effect on lipoproteins

A

high VLDL

high LDL

high TG

excess apob100

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16
Q

familial hypercholeseterolemia

A

usually receptor defect

excess LDL

17
Q

familial hypoalphalipoproteinemia

A

low HDL

apoA deficiency or ABCA1 problem

18
Q

adverse effects of niacin

A

flushing

GI

hepatotoxicity

hyperglycemia