18 Aorta

Question 1

fibrillar collagen resides mostly in what layer of the aorta

Answer 1

adventitia

Question 2

elastin is most abundant in which layer of the aorta

Answer 2

media

Question 3

marfan syndrome is a deficiency in….

Answer 3

fibrillin; COL1A2 gene defect

weaker walls due to less fibrillin predisposes to aortic dissection, thoracic aneurysm

Question 4

ehlers-danlos type IV

Answer 4

collagen deficiency; COL3A1 mutant

propensity for aneurysms/dissection

Question 5

complications of dissecting aorta

Answer 5

pericardial tamponade(most common cause of death)

rupture w/fatal hemorrhage

pinching off of branch vessels(renal a.) –> end organ ischemia

Question 6

common causes of thoracic aneurysms

Answer 6

tertiary sphyillus(vasovasorum to outer layer of aorta is closed off, weakening outer wall)

central medial necrosis from marfan syndrome