8/28/13

Question 1

What type of receptors and ligans do mature T-cells express when they migrate to sites of infections and what do they bind to on the endothelium

Answer 1

E, P selectin ligand–>E, P selectin
LFA1, VLA-4–> ICAM, VCAM
CXCR3–> CXCL10

Question 2

What molecule on helper T-cells acts as a safeguard emsuring that only macrophage presenting the correct antigen are activated?

Answer 2

CD40 ligand

Question 3

TH17 attracts (macrophages/neutrophils)

Answer 3

Neutrophils

Question 4

How do IgE antibodies help remove a parasitic worm and which helper T-cell stimulates this antibody production?

Answer 4

IgE antibody bind to Fc receptors on the worm, leading to cross-linking which in turn signals degranulation. Degranulation from eosinophils will destruct the worm. TH2 stimulates the antibody

Question 5

If there is a significant amount more TH1 cells than TH2 cells in the body, this type of leprosy may occur

Answer 5

Tuberculoid leprosy

Question 6

If there is a significant amount more TH2 cells than TH1 cells in the body, this type of leprosy may occur

Answer 6

Lepromatous leprosy

Question 7

Do all of the MHC alleles need to be in common between a donor and recipient so that target cells can be killed via CD8 T-cells?

Answer 7

No

Question 8

What types of granules does killer T-cells release when it is bound to the appropriate target cell?

Answer 8

Perforin, Granzymes

Question 9

Which Grnazyme mediates apoptosis via caspase 3 (a,b,c)

Answer 9

b

Question 10

What are 3 general cell mediated evasion strategies?

Answer 10

prevent phagosome killing, inhibit antigen presentation by MHC I, and interference with cytokine signaling