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PHD Block 1, MUSC '13 > 8/20/13 > Flashcards

8/20/13 Flashcards

Introduction to Immune System

1
Q

Type of immunity that recognizes molecules common to many pathogens

A

Innate Immunity

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2
Q

Type of immunity that recognizes very specific macromolecules

A

Adaptive Immunity

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3
Q

An antigen that can induce an immune response

A

Immunogen

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4
Q

An antigen that cannot induce an immune response

A

Hapten (unless coupled with immunogen)

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5
Q

Present peptide antigens to T-cells, determine tissue type for organ transplantation

A

MHC

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6
Q

All leukocytes differentiate from this

A

hematopoetic stem cells in the bone marrow

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7
Q

Immunity is conferred on individual when they are themselves infected or vaccinated

A

Active immunity

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8
Q

If effectors are transferred from one individual to another, they confer_____

A

Passive Immunity

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9
Q

Granulocytes/Polymorphonuclear cells

A

Neutrophils, Eosinophils, Basophils

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10
Q

Short-lived Leukocyte, innate

A

Granulocytes (monocytes in b/w)

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11
Q

Long-lived Leukocyte, adaptive

A

Lymphocytes, NK cells are innate (monocytes in b/w)

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12
Q

Granulocytes recognize ____ targets by the presence of ______ and particles coated by _____. Granulocytes have an _____ ability to recognize a foreign invader

A

multiple, PAMPS, antibodies

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13
Q

Lymphocytes recognize ____ target shape and a _____ fraction will be activated by a particular pathogen or invader

A

one, small

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14
Q

Play a major role in late phase of hypersensitivity reactions

A

Eosinophils

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15
Q

Play a major role in the immediate phase of hypersensitivity reaction

A

Basophils

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16
Q

Antigen presenting cells that bridge the innate and adaptive immune systems

A

Monocytes (become macrophages in tissue)

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17
Q

Lymphocyte differentiated in bone marrow

A

B-cells

18
Q

Lymphocyte differentiate in thymus

A

T-cells

19
Q

Leukocytes not usually found in blood

A

Plasma Cells, Mast Cells, Macrophages, Dendritic cells, follicular dendritic cells

20
Q

After stimulation by appropriate target/antigen, all lymphocytes undergo ______

A

Clonal Expansion

21
Q

Cells that are important for presenting antigen for B-cells

A

Follicular Dendritic Cells

22
Q

CD3, CD19

A

T-cells, B-cells

23
Q

Primary (Generative) Lymphoid tissues

A

Bone Marrow, Thymus

24
Q

Secondary (peripheral) Lymphoid Tissues

A

Spleen, lymph nodes, Tonsils, MALT

25
Q

Tertiary (ectopic) Lymphoid tissue

A

Pathology associated

26
Q

Primary lymphoid tissue generates mature naive lymphocytes from immature progenitor cells in this process

A

Lymphopoiesis

27
Q

Primary location of plasma cells

A

bone marrow

28
Q

Provide an environment for target/antigen focusing and serve as a storage depot for mature lymphocytes

A

Secondary Lymphoid tissues

29
Q

Location of B-cells in lymph node

A

Outer cortex arranged into follicles w/ follicular dendritic cells

30
Q

Location of T-cells in lymph node

A

interdigitating paracortex with high endothelial venules

31
Q

Samples the mucosal fluids for paticulates, bacteria, and viruses.

A

MALT

32
Q

In the spleen, capillary sinuses lined with phagocytic endothelium and macrophages that act as a filter and capture antigens

A

Red Pulp

33
Q

In the spleen, lymphocytes

A

White Pulp

34
Q

Lymphoid-vascular interface in the spleen

A

Marginal zone

35
Q

How do T and B-cells organize into their respective territories in lymph nodes and the spleen?

A

Respond to different chemokines that bind to receptors on their cell surface

36
Q

Antigen stimulate follicle

A

Germinal center

37
Q

Support high levels of lymphocyte extravasation from the blood

A

High endothelial venules

38
Q

T>B

A

peripheral blood, thoracic duct, lymph nodes, thymus

39
Q

T=B

A

spleen

40
Q

B>T

A

bone marrow, peyer’s patch

PHD Block 1, MUSC '13 (8 decks)

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