8/22/13 Flashcards
B-cell antigen receptor can recognize_____
all types of things such as proteins, small chemicals, polysaccarides
T-cell antigen receptor can recognize______
only small peptides displayed on molecules called MHC
CD4
Helpter T-cells
CD8
Cytotoxic T-cells
APC express which classes of MHC?
Type 1 and 2
All cells in the body express which class of MHC
Type 1
Three types of APC cells
Dendritic cells (naive lymphocytes), macrophages (effector lymphocytes), and B-cells (CD4, humoral response)
What receptor leads the dendritic cell to the T-cell area in the lymph node?
CCR7 receptor
Pathogens in the lymph will be phagocytosed and presented by DC where?
Lymph nodes
Pathogens in the blood will be phagocytosed and presented by DC where?
Spleen
Pathogen endocytosed from the extracellular environment is presented on
MHC II
Antigens from the cytoplasm of the APC are presented on
MHC I
MHC II interacts with which type of T-cell
CD4 at beta 2
MHC I interacts with which type of T-cell
CD8 at alpha 3
MHC I peptide groove includes these structures
alpha1,2
MHC II peptide groove includes these structures
alpha 1, beta 1
What are the genes that encode MHC I?
HLA-A,B,C (codominant so a total of 6 different MHC I molecules on cells in the body)
What are the genese that encode MHC II?
HLA-DP,DQ, DR
MHC II pathway
Extracellular antigens enter APC and are contained within endosome–> endosome and lysosome beging to fuse–>on the ER the subunit of MHC are produced and then CLIP is inserted to the peptide binding site–> the exocytic vesicle fuses with the endosome–> HLA-DM replaces the CLIP with the peptide–> MHC II with peptide is presented to CD4
MHC I pathway
Intracellular protein is ubiquinated–> taken to proteasome and cleaved–> peptide enters ER via TAP–> binds toe peptide groove of MHC I–> presented to CD8
