8/22/13

Question 1

B-cell antigen receptor can recognize_____

Answer 1

all types of things such as proteins, small chemicals, polysaccarides

Question 2

T-cell antigen receptor can recognize______

Answer 2

only small peptides displayed on molecules called MHC

Question 3

CD4

Answer 3

Helpter T-cells

Question 4

CD8

Answer 4

Cytotoxic T-cells

Question 5

APC express which classes of MHC?

Answer 5

Type 1 and 2

Question 6

All cells in the body express which class of MHC

Answer 6

Type 1

Question 7

Three types of APC cells

Answer 7

Dendritic cells (naive lymphocytes), macrophages (effector lymphocytes), and B-cells (CD4, humoral response)

Question 8

What receptor leads the dendritic cell to the T-cell area in the lymph node?

Answer 8

CCR7 receptor

Question 9

Pathogens in the lymph will be phagocytosed and presented by DC where?

Answer 9

Lymph nodes

Question 10

Pathogens in the blood will be phagocytosed and presented by DC where?

Answer 10

Spleen

Question 11

Pathogen endocytosed from the extracellular environment is presented on

Answer 11

MHC II

Question 12

Antigens from the cytoplasm of the APC are presented on

Answer 12

MHC I

Question 13

MHC II interacts with which type of T-cell

Answer 13

CD4 at beta 2

Question 14

MHC I interacts with which type of T-cell

Answer 14

CD8 at alpha 3

Question 15

MHC I peptide groove includes these structures

Answer 15

alpha1,2

Question 16

MHC II peptide groove includes these structures

Answer 16

alpha 1, beta 1

Question 17

What are the genes that encode MHC I?

Answer 17

HLA-A,B,C (codominant so a total of 6 different MHC I molecules on cells in the body)

Question 18

What are the genese that encode MHC II?

Answer 18

HLA-DP,DQ, DR

Question 19

MHC II pathway

Answer 19

Extracellular antigens enter APC and are contained within endosome–> endosome and lysosome beging to fuse–>on the ER the subunit of MHC are produced and then CLIP is inserted to the peptide binding site–> the exocytic vesicle fuses with the endosome–> HLA-DM replaces the CLIP with the peptide–> MHC II with peptide is presented to CD4

Question 20

MHC I pathway

Answer 20

Intracellular protein is ubiquinated–> taken to proteasome and cleaved–> peptide enters ER via TAP–> binds toe peptide groove of MHC I–> presented to CD8