8 Flashcards
what is the mechanism of action of rivastigmine ?
a. cholinesterase inhibitor
b. alpha 1 receptor inhibitor
c. serotonin reuptake inhibitor
d. angiotensin converting enzyme inhibitor
a. cholinesterase inhibitor
page 1
which one of the following toxins can be used therapeutically?
a. aflatoxin
b. saxitoxin
c. alpha bungarotoxin
d. botulinum toxin
d. botulinum toxin
page 1
what is the recommended immunization schedule for tuberculosis ?
a. at birth
b. 6 weeks ,2 months , 6 months
c. 2,4, and 6 months
d. 6,12,and 18 months
a. at birth
page 1
what is the therapeutic effect of benzoyl peroxide in treatment of acne ?
a. keratolytic
b. antifungal
c. emollient
d. antiviral
a. keratolytic
page 2
what is the recommended immunzation schedule for measles , mumps and rubella vaccine?
a. birth
b. 6 weeks ,2 months , 6 months
c 2,4, and 6 months
d. 12 months an 4 years
d. 12 months an 4 years
page 2
a 27 year old man suffer form hepatitis c virus infection. His level of alanine aminotransferase and aspartate aminotransferase are high. In addition, liver biopsy showed mild fibrosis ( see lab results ).
test result normal values
alanine aminotrasnferase 75 5-40
aspartate aminotrnsferase 55 12-40 IU/L
which one of the followin drugs should be avoided in his case?
a. cephalexin
b. ampicillin
c. pregabalin
d. methotrexate
d. methotrexate
page 3
a diabetic patient has been diagnosed with hyperliidemia ( see lab results).
test result normal values
total cholesterol 6.5 <5.1 mmol/L
triglycerides 3.2<2.16 mmol/L
which one of the following drugs is the best option
a. ezetimibe
b. gemfibrozil
c. atorvastatin
d. cholestyramine
c. atorvastatin
page 4
which one of the following is a contra-indication of labetalol therapy?
a. anxiety
b. severe asthma
c. morning sickness
d. irritable bowel syndrome
b. severe asthma
page 4
what is the antidote for cholinesterase inhibitor mild toxicity?
a. atropine
b. carnitine
c. deferoxamine
d. sodium thiosulfate
a. atropine
page 5
a 49 year old man has high blood pressure despite following life style modification recommendations. HIs doctor is nor considering initiating treatment.
Which of the following drugs would be most appropriate?
a. doxazosin
b. lisinopril
c. propranolol
d. spironolactone
b. lisinopril
page 5
which of the following is a contraindication to the use of methotrexate?
a. pregnancy
b. tachycardia
c. pheochromocytoma
d. uncontrolled hypertension
a. pregnancy page 6
which of the folowing is a contraindication to isotretinoin therapy?
a. gallstones
b. essential hypertension
c. elevated blood lipid values
d. concomitant use with proton pump inhibitor
c. elevated blood lipid values
page 6
which of the following conditions is a serious adverse reaction of fluoroquinolone therapy?
a. eczema
b.. depression
c. nerve damage
d. abdominal pain
c. nerve damage
page 6
which of the following is a contraindication to isotretinoin therapy ?
a. gallstones
b. essential hypertension
c. elevated blood lipid values
d. concomitant use with proton pump inhibitors
c. elevated blood lipid values
page 7
which of the following conditions is a serious adverse reaction of fluoroquinolone therapy?
a. eczema
b. depression
c. nerve damage
d. abdominal pain
c. nerve damage
page 7
a 55 year old man presented to the hypertension clinic with uncontrolled blood pressure. He is currently using amlodipine 10mg per day. Ankle swellilng was observed during examination. A dipstick urine analysis revealed trace proteinuria.
blood pressure 160/100 mmHg
what will be the best drug to add in his prescription?
a.prazosin
b. enalapril
c. clonidine
d. metoprolol
b. enalapril
page 8
what is the validity of a registration certificate for pharmacy premises?
a. one year
b. three year
c. five years
d. ten year
c. five year
page 8
a 47 year old man was admitted to a psychiatric hospital in an acute psychotic state. her symptoms did not improve despite the use of adequate doses of two different anti-psychotic gents. the doctor is now cosidereing clozapine for her consition.
which of the following tests shoudl be carried out before initiation clozapine therapy?
a. presgnancy test
b. john cunningham virus DNA test
c. baseline absolute neutrophil count
d. magnetic resonance imaging of brain
c. baseline absolute neutrophil count
page 9
what is compassionate use of drug?
a. use of unapproved drug for seriously ill patient
b. use of approved drug in any patient
c. use of drug in wrong population
d. irrational drug use
a. use of unapproved drug for seriously ill patient
page 9
which of the following studies could establish the drug shelf life?
a. bioavailability
b. bioequivalennce
c. stability studies
d. pharmcodynamic
c. stability studies
pge 10
which one of the following is a seious adverse drug reaction?
a. urine discoloration caused by metronidazole
b. hospitalization due to bleeding caused by warfarin
c. tacycardia caused by salbutamol
d. throbbing headche caused by sildenafil
b. hospitalization due to bleeding caused by warfarin
page 10
which of the following can potential digoxin toxicity?
a. orlistat
b. migraine
c. amoxicillin
d. hypokalemia
d. hypokalemia
page 10
a 39 year old woman present to gastroentetology clinic with the chief complaint of bloody stool and weakness. Upon examination, no palpable mass was observed. Endoscopy reveal abnormal erythematous mucosa with ulceration. Her doctor told her that she has mild ulcerative colitis.
what would be the appropriate management?
a. bevacizumab
b. cyclosporine
c. sulfasalazine
d. pembrolizumab
c. sulfasalazine
page 11
which of the following is a contraindication to the use of lisinopril?
a. porphyria
b. addisons disease
c. history of angioedema
d. high grade aortic stenosis
c. history of angioedema
page 11
which one of the following tasks is among the responsibilities of scientific office of any pharmaceutical comany?
a. ensures compliance with good manufacturing practice
b. maintains technical support for company’s databases
c. conducts post marketing surveillance of products
d. supervises analytical procedures
c. conducts post marketing surveillance of products
page 12
which of teh following drugs is used to treat acute ischemic stroke?
a. galantamine
b. lactulose
c. ivabradine
d. alteplase
D. ALTEPLASE
page 12
a pharmacist is planning to establish a plant for pharmaceutical products. He learned that the platn should follow good manufacturing practice guidelines issued by the saudi food and drug authority.
what does good manufacturing practice mean?
a. proper distribution of medical products
b. ehtical and scientific quality requirements that must be followed for clinical trials
c. minimum standard that a medicines manufacturer must meet in their production processes
d. documented best practice for processing, formatting and management of product rev
c. minimum standard that a medicines manufacturer must meet in their production processes
page 13
what is the antidote for heparin toxicity?
a. protamine sulfate
b. sodium salicyalte
c. naloxone
d. glucgon
a. protamine sulfate
page 14
whihc one of the following agents might cause neurophathy?
a. naproxen
b. magnesium
c. memntine
d. doxorubicin
d. doxorubicin
page 14
why aspirin should be avoided in children?
a. risk of bone deformity
b. risk of reyes syndrome
c. risk of tendons damage
d. risk of kawasakis disease
b. risk of reyes syndrome
page 14
a 17 year old women presents to the eergency department due to paracetamol dose, she reports anorexia, nusea, vomiting and malaise. She has taken to control her throbbbing headache.
which one of the following will be the most appropriate treatment?
a. pyridoxine
b. diphenoxylate
c. physostigmine
d. acetylcysteine
d.acetylcysteine
page 15
a 83 year old man has been diagnosed with parozysmal atrial fibrillation with heart failure. he is prescribed amiodarone.
whih of the following shoudl he avoid?
a. papaya
b. carrots
c. watermelon
d. grapefruit
d. grapefruit
page 15
which one of the following agents is a controlled drug that needs narcotic drugs prescription?
a. chlorzoxazone
b. pethidine
c. zafirlukast
d. levodopa
b. pethidine
page 16
why doxycycline should be avoided in children less than 12 years?
a. high toxicity
b. low tolerability
c. risk of bleeding
d. teeth discoloration
d. teeth discoloration
page 16
In which age group cough and cold medications is contraindicated in Saudi?
a. children under 2 years old
b. children under 1 year old
c. children under 6 year old
d. adolescents under 18 year old
c. children under 6 year old
page 16
A 42 year old woman presents with rapidly evolving severe relapsing remitting multiple sclerosis. She had two disabling relapses during MRI showed Gadolinium enhancing lesions.
what would be the best orally administered drug for her condition?
a. Natalizumab
b. Ranibizumab
c. Pertuzumab
d. Fingolimod
d. Fingolimod
page 17
A 46 year old man presented to the Neurology clinic with highly active repalsing remitting multiple sclerosis despite adequate course of treatment with a disease modifying therapy. His doctor decided to prescribe fingolimod.
which one of the following assessments is crucial prior to fingolimod dosing?
a. HLA -B * 5701
b. electrocardiography
c. arylsulfatase A level
d. sensitivity testing
b. electrocardiography
page 17
a 48 year man suffers form heartburn and difficulty in swallowing food. The endoscopy shows signs of gastroesophageal reflux disease. His doctor prescribed esomeprazole 40 mg.
which of the following should be recommended?
a. use when needed
b. should be used for one month
c. should be stopped if hypoglycaemia occurs
d. regular follow up to check electrolytes imbalance
d. regular follow up to check electrolytes imbalance
page 18
