2 Flashcards
long acting analgesic and anti-inflammatory drug?
Decrease prostaglandin
Most likely drug causes Peptic ulcer?
Piroxicam Or Ketorolac Or Indomethacin
Man take overdose from drug then take the antidote but still no effect, why?
( antidote dose was small )
- Biological substance can be stored at … C
2 – 8 C
What pharmacist should do when wrong medication prescribed from Dr?
Inform prescriber doctor
What should do with elderly man with hypertension?
start with small initial dose then increase
What should do with girl has seizure and tremor رعشه when use Oxcarbazepine “anti-convulsant” ?
( shift to Topiramate ) “Topamax”
TTT of trigeminal neuralgia ?
( Carbamazepine ) “Tegretol”
10.Child taking Oxcarbazepine suffers from rash and redness, ?
shirf to Topiramate Or Ethosuximide
N.B ; this shifting is due to the child because this S.E is normal side effect ,, in case of adult ; keep using Oxcarbazepine
Medication is used to treat absence seizures ?
( Ethosuximide )
Pt suffered before from migraine attack with aura, he needs drug as prophylaxis?
Topiramate 25 mg twice
13.Middle age man has HbA1c=9 and he takes Glipizide + Lisinopril + Pioglitazone Dr add ?
( insulin )
Example of drug - disease interaction?
( Pioglitazone & heart failure ) ( Celecoxib & Cardiac toxicity )
Woman wants to be pregnant, she takes metformin and pioglitazone, she has history of hypoglycemic and prefers oral therapy,
best TTT?
( Stop pioglitazone and titrate metformin )
N.B ; side effect of pioglitazone is Hypoglycemic
16.Normal range of HbA1c is ; non-diabetic
4 – 5.6
Bioavailability of Diclofenac injection in muscle ;
100%
Bioavailability refers to extent and rate at which the active moiety enters…..?
( systemic circulation ) “site of action”
Heparin & Warfarin are contra-indicated with?
( Aspirin & Diclofenac & ibuprofen )
20.Heparin or Warfarin if I added to Aspirin will lead to?
( Bleeding )
Interaction between warfarin and ibuprofen cause risk of bleeding, why?
( warfarin will be replaced by ibuprofen )
22.Warfarin oral anti-coagulant is determined or calculated by?
( INR international normalized ratio )
23.Heparin injection anti-coagulant is determined by?
( APTT activated partial thromboplastin time )
24.Heparin and warfarin were prescribed for patient, how long he will take heparin and how much INR ?
( take heparin for 2 days with warfarin then stop heparin , warfarin biological T1/2 is 48 hours
Best counseling point for patients taking warfarin?
( Vit K consistent )
Anti-dote of warfarin?
Vitamin K other name Phytomenadion , phylloquinone K1 , menaquinone K2 , menadione K3
Anti-dote of Heparin?
Protamine sulfate
28.Anti-dote of Paracetamol?
N-Acetyl Cysteine
Anti-dote of iron? Deferoxamine
Drug acts on non-receptor mechanism?
Drug is used to remove excess iron by binding to free iron?
Deferoxamine
Which decreases warfarin actions?
Multivitamins
31.Which drug cause nasal bone hypoplasia?
Warfarin
32.Drug that increases action of Warfarin?
None of the above
33.Why should warfarin be stopped if woman want to be pregnant?
Cranial facial abnormality
34.Warfarin affects ? the vitamin K dependent clotting factors II , VII , IX , X
Heparin increase ?
the vitamin K dependent clotting factors II , VII , IX , X
Heparin increase ? increases the action of anti-thrombin on thrombin and factor Xa
35.Decrease or increase dose to the patient by technician is? Omission error الجرعه في خطأ اي Or ( improper dose error )
Omission error الجرعه في خطأ اي Or ( improper dose error )
36.Types of error in Pharmacy?
dispensing error
37.Nurse gives patient dose 2 hours later, what is the type of error?
wrong time error , administration error
38.Example of error of deteriorating drug?
giving expired drug , storing drug out Refrigerator
39.Most occurring error in prescription?
wrong drug order
40.Most error that may occur when patient is transferred from one unit of facility to another?
missing drug he was taking
Dr prescribes Chlorpheniramine for driver but the pharmacist discover problem?
the error occur and drug won’t reach Pt
42.Barbiturates are Sedatives, Analgesics, and anti-convulsant Ex / ……barbital
ultra short barbiturates are used mainly?
Anesthesia Ex / methohexital - thiopental - thiamylal
43.Side effect of Barbiturates in elderly patient?
Agitation Or Excitement confusion موجودين مش االتنين لو
44.Drug with slow metabolism?
Phenobarbital ; that is short acting barbiturate
45.Anti-fungal Amphotericin B is used for what infection?
Systemic & Subcutaneous
46.Acyclovir is used for?
Herpes simplex virus
47.MOA of anti-emetic Metoclopramide ?
dopamine D2 antagonist “dopamine blocker” , agonist on serotonin 5-HT4 receptor , weak inhibition of 5-HT3 receptors
48.Metoclopramide action on which area?
Chemo trigger zone
49.Which drug increase milk production by increase prolactin level?
Metoclopramide , Domperidone
Which drug decrease milk supply?
Ergotamine , Estrogen , bromoceptrin
TTT of nausea and vomiting in Breastfeeding?
Domperidone “anti-emetic without CNS effect” , Metoclopramide
Duration of using Domperidone?
3 – 5 Days not be used for more than 7 days اسبوع مده اقصي
MOA of domperidone?
Dopamine antagonist & can’t cross BBB
MOA of Doxazosin ?
inhibits postsynaptic alpha 1 adrenergic receptor
Duration of Esomeprazole in gastroesophagial disease?
up to 24 hours
.Esomeprazole for esophageal injury?
30 days
Which committee rules out a drug from the hospital?
Therapeutic evaluation committee
Non formulary drug order reviewed by?
= Management of the drug? Pharmacy & therapeutic committee
Formula of drug can be adjusted by?
= Removing a drug from formulary? Pharmacy & therapeutic committee
MOA of statin?
Decrease cholesterol by inhibiting HMG-CoA reductase
