7- Drugs Used In Blood Disorders

Question 1

Direct thrombin inhibitors ? Their uses ?

Answer 1

1- Argatroban : in heparin induced thrombocytopenia

2- Dabigatran : in AF ( reversed by Idarucizumab )

3- Bivalirudin : used with aspirin in unstable angina when undergoing PTCA

Question 2

Direct factor Xa inhibitor ? Uses ?

Answer 2

Rivaroxaban

To prevent DVT after knee/hip surgery
Prevention of stroke and systemic embolism in non-valvular atrial fibrillation

Question 3

Streptokinase MOA ?

Answer 3

Acts on both bound and free plasminogen depleting circulating plasminogen and factors V and Vlll

Question 4

Alteplase MOA ?

Answer 4

Acts on fibrin bound plasminogen, the natural activator so no allergy problems

Question 5

Side effects of streptokinase ?

Answer 5

Hypersensitivity reactions

Hypotension

Question 6

Antidote in case of excessive bleeding with streptokinase ?

Answer 6

Antifibrinolysins as :
Aminocaproic acid
Tranexamic acid

Question 7

Drug that decrease infarct size in case of MI ?

Answer 7

Adenosine

Question 8

ADP receptor blockers ? Uses ? Side effects ?

Answer 8

Clopidogrel
Prasugrel
Ticagrelor

Alternative to aspirin in TIAs , post-MI , unstable angina

Hemorrhage
Leukopenia
Thrombocytopenic purpura

Question 9

Aspirin + ADP receptor blockers are used in ?

Answer 9

Patient with non-ST elevation ACS

Question 10

GP llb/llla blockers ? Uses ?

Answer 10

Abciximab
Eptifibatide
Tirofiban

Question 11

Platelet aggregation increased by ?

Answer 11

ADP
5HT
TxA2
Thrombin 
Alpha2 agonists

Question 12

Platelet aggregation decreased by ?

Answer 12

PGI2 
cAMP
ASA
Clopidogrel 
GP llb/llla

Question 13

Warfarin can be displaced from blood proteins by which drugs ?

Answer 13

ASA 
Sulfonamides 
Phenytoin 
Sulfinpyrazone 
Chloral hydrate