3- CVS And Renal Flashcards
Site of action of K sparing diuretics ?
Early collecting duct
Selective aldosterone receptor blocker devoid of antiandrogenic effect ?
Eplerenone
2 drugs that have side effect of causing gingival hyperplasia ?
-dipines
Phenytoin
Chronic hypertension in pregnancy is ttt with ? Preeclampsia is ttt with ?
Methyldopa , labetalol
Hydralazine , labetalol
Phosphodiesterase inhibitor drugs ?
Inamrinone
Milrinone
Which class of antiarrhythmic drugs slows the repolarization phase of action potential ?
Class lll
Which class of antiarrhythmic drugs slows or blocks phase 0 in slow response fibers ?
Class lV
Which class of antiarrhythmic drugs can slow phase 4 ( pacemaker current ) in pacemaker fibers ?
Class ll and Vl
Mechanism of action of class 1A antiarrhythmic drugs ? Examples ?
Block fast Na channels preferentially in the open state
Also blocks K channel
Quinidine
Procainamide
Mechanism of action of class 1B antiarrhythmic drugs ? Examples ?
Blocks inactivated fast Na channels
Blocks slow Na “window” currents —> decreases APD
Lidocaine
Mexiletine
Mechanism of action of class 1C antiarrhythmic drugs ? Example ?
Blocks fast Na channels
Flecainide
Mechanism of action of class lll antiarrhythmic drugs ? Examples ?
K channel ( delayed rectifier current ) blockers
Amiodarone
Sotalol
Mechanism of action of class lV antiarrhythmic drugs ? Examples ?
Ca channel blockers
Verapamil
Deltiazem
Drugs that causes torsades ?
1- K channel blockers ( class 1A and lll antiarrhythmic drugs )
2- Antipsychotics ( thioridazine )
3- Tricyclic antidepressants
Mechanism of action of Ranolazine in ttt of angina ?
Blocks late inward Na current in cardiac myocytes , there by decreasing Ca accumulation by decreasing Na/Ca exchange pump
