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Pharmacology > 1- General > Flashcards

1- General Flashcards

1
Q

1A2 cytochrome P450 Isozyme substrate examples ? Inducers ? Inhibitors ?

A

Theophylline
Acetaminophen

Aromatic hydrocarbons ( smoke ) 
Cruciferous vegetables

Quinolones
Macrolides

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2
Q

2C9 cytochrome P450 Isozyme substrate examples ? Inducers ? Inhibitors ?

A

Phenytoin
Warfarin

General inducers of cytochrome P450 isozymes

No inhibitors

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3
Q

2D6 cytochrome P450 Isozyme substrate examples ? Inducers ? Inhibitors ?

A

Many cardiovascular and CNS drugs

No inducers

Haloperidol
Quinidine
SSRIs

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4
Q

3A4 cytochrome P450 Isozyme substrate examples ? Inducers ? Inhibitors ?

A

60 % of drugs in PDR

General inducers

General inhibitors
Grapefruit juice

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5
Q

General inducers of cytochrome P450 isozymes ?

A

Anticonvulsants ( barbiturates , phenytoin , carbamazepine)
Antibiotics ( rifampin )
Chronic alcohol

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6
Q

General inhibitors of cytochrome P450 isozymes ?

A

Antiulcer medications ( cimetidine , omeprazole )
Antimicrobials ( chloramphenicol, macrolides , ritonavir , ketoconazole )
Acute alcohol

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7
Q

Drugs that cause drug induced systemic lupus ?

A

Hydralazine
Procainamide
Isoniazid

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8
Q

Morphine is activated by ?

A

Glucuronidation

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9
Q

Chloramphenicol causes grey baby syndrome in neonates due to reduced activity of ?

A

Glucuronidation

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10
Q

Examples for drugs with zero order elimination rate ?

A

Ethanol
Phenytoin
Salicylates

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11
Q

Equation of half life of a drug ?

A

T = .7 x ( Vd / Cl )

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12
Q

Infusion rate equation ?

A

Infusion rate = Cl x Css

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13
Q

Loading dose equation ?

A

Loading dose = ( Vd x Cp ) / f

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14
Q

Maintenance dose equation ?

A

Maintenance dose = ( Cl x Css x T ) / f

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15
Q

Examples for hormones that act through intracellular receptors ?

A

Glucocorticoids
Thyroid hormones
Gonadal steroids
Vitamin D

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16
Q

Examples for receptors that are directly coupled to ion channels ?

A

Nicotinic receptors

GABAa receptors in CNS

17
Q

Examples for receptors coupled to Gs protein ?

A 
Beta receptors
D1 receptor 
Glucagon receptors 
H2 receptors 
Prostacyclin receptors 
Some serotonin serotypes
18
Q

Examples for receptors coupled to Gi protein ?

A

Alpha2 receptors
M2 receptors
D2 receptors
Several opioid and serotonin subtypes

19
Q

Examples for Receptors that are coupled to Gq protein ?

A

M1 and M3 receptors
Alpha1 receptors
Angiotensin ll receptors
Several serotonin subtypes

20
Q

Examples for drugs that are irreversible inhibitors that have therapeutic effect long after the drug has been eliminated ?

A

Aspirin
PPIs
MAOIs

21
Q

Guanyl cyclase associated receptors ?

A

ANP receptors

22
Q

A specific tyrosine kinase inhibitor ?

A

Imatinib

23
Q

A non specific tyrosine kinase inhibitor ?

A

Sorafenib

Pharmacology (9 decks)

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