6.6 Hormones, homeostasis and reproduction Flashcards

1
Q

The Endocrine System

A

A stimulus is received and processed.
Hormones are secreted directly into the blood.
They are carried to the target tissues.
The action of the hormone changes the condition of the tissue.
This change in monitored through feedback.
Most hormonal change results in negative feedback (corrects the imbalance)

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2
Q

Key endocrine glands:

A

Pineal gland
Pituitary gland
Thyroid gland
Thymus
Adrenal gland
Pancreas
Ovary (female)
Testes (male)

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3
Q

Blood glucose is maintained through the actions of the…

A

pancreas and the liver

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4
Q

Pancreatic hormones insulin and glucagon regulate …

A

blood glucose levels

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5
Q

islets of Langerhans

A

small regions of the pancreas that secrete hormones directly into the blood

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6
Q

If blood glucose levels DROP:

A

pancreas detects drop
𝛂 cells create/secrete glucagon hormone
glucagon stimulates the liver to convert stored glycogen into glucose and its release into the blood
blood glucose increases (to normal)

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7
Q

If blood glucose levels RISE:

A

pancreas detects rise
β cells create/secrete insulin
Insulin stimulates uptake of glucose by various tissues (skeletal/muscle)
Insulin stimulates liver to convert blood glucose into stored glycogen
blood glucose drops (to normal)

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8
Q

Diabetes

A

consistently elevated blood glucose levels
Damages tissues and their proteins
Prevents water reabsorption in kidneys 🡪 increase in volume of urine & body dehydration
Symptoms: constant urination, constant thirst, tired, craves sugar, glucose in urine

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9
Q

Type I diabetes (early onset)

A

Cannot produce enough insulin
Autoimmune disease
Destruction of β cells in islets of Langerhans by immune system

Treatment
Testing blood glucose levels regularly and injecting insulin when too high
Implant devices to release insulin
Stem cell treatment to create new β cells

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10
Q

Type II diabetes (late onset)

A

Cannot respond to insulin
Lack of insulin receptors or glucose transporters on target cells
Risk factors: sugary/fatty diets, prolonged obesity, genetic factors that affect metabolism

Treatment
Adjusting diet
Frequent, smaller meals
Avoid sugary foods
Eat foods with low glycemic index (digested slowly
High fiber foods
Exercise

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11
Q

Type II diabetes (late onset)

A

Cannot respond to insulin
Lack of insulin receptors or glucose transporters on target cells
Risk factors: sugary/fatty diets, prolonged obesity, genetic factors that affect metabolism

Treatment
Adjusting diet
Frequent, smaller meals
Avoid sugary foods
Eat foods with low glycemic index (digested slowly
High fiber foods
Exercise

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12
Q

Thyroxin

A

Produced by: thyroid gland
Structure: four iodine atoms
Targets: most body cells (liver, muscle, brain)
Effects:
increases metabolic rate/rate of protein synthesis
increases heat production when body temp. is low (e.g. increased respiration)

Thyroxin deficiency (hypothyroidism)
Tired/lack of energy
Forgetfulness
Depression
Decrease appetite & weight gain (less glucose/fat broken down by cell respiration)
Feel cold
Constipation (muscle contractions in gut slow down)
Impaired brain development in children

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13
Q

Leptin

A

Produced by: adipose cells (fat storage cells)
Targets: appetite control centre of the hypothalamus (in brain). Leptin binds to receptors in cell membranes
Effects:
Increase in adipose tissue increases leptin secretions into the blood
Appetite inhibition → reduced food intake

Mice and leptin
Mice with two recessive alleles ob/ob were found to be obese
Wild-type allele supports synthesis of leptin
ob/ob mice injected with leptin showed decline in appetite

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14
Q

Melatonin

A

Produced by: pineal gland in darkness
Controlled by: suprachiasmatic nuclei (SCN) in the hypothalamus
Targets: pituitary and other glands
Effects:
synchronization of circadian rhythms (24-hr cycle)

Circadian rhythms
Controlled by two groups of cells in the hypothalamus (brain)
Control secretion of melatonin by pineal gland to regulate sleep cycle → increases at night, decreases at dawn
increase in melatonin at night drops body temp. and possibly reduces urine production
Light detected by retina helps to set circadian rhythm
Even if kept in environment without light cues, body’s circadian rhythm will be mostly maintained

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15
Q

Sex determination

A

in embryos the first appearance of the gonads is essentially the same in the two sexes. Gonads could become either ovaries or testes.

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16
Q

SRY gene

A

encodes for a protein known as testis determining factor (TDF).

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17
Q

TDF

A

is a DNA binding protein which acts as a transcription factor promoting the expression of other genes that cause testis development..

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18
Q

In the absence of TDF

A

the gonads become ovaries and the developing fetus becomes female.

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19
Q

Testosterone

A

The testes develop from the embryonic gonads when the the embryo is becoming a fetus. They develop testosterone-secreting cells.

The testes secrete testosterone which causes the male genitalia to develop.

At puberty the secretion of testosterone increases causing:
The primary sexual characteristic of sperm production in the testes
Development of secondary sexual characteristics such as enlargement of the penis, growth of pubic hair and deepening of the voice

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20
Q

Estrogen and progesterone

A

n the absence of fetal testosterone and the presence of maternal estrogen and progesterone, female reproductive organs develop (ovaries develop from the embryonic gonads) due to:
estrogen and progesterone
No testosterone

Estrogen and progesterone are present. At first they are secreted by the first by the mother’s ovaries and later by her placenta.

At puberty the secretion of estrogen and progesterone increases causing:
Primary sexual characteristic of egg release
Development of female secondary sexual characteristics such as enlargement of the breasts and growth of pubic hair

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21
Q

uterus

A

provides protection, nutrients and waste removal for the developing fetus
Muscular walls contract to aid birthing process

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22
Q

oviduct (fallopian tube)

A

Connects the ovary to the uterus
Fertilisation of the egg occurs here

23
Q

ovary

A

Produce eggs, estrogen and progesterone

24
Q

endometrium (lining of the uterus)

A

develops each month in readiness for the implantation of a fertilised egg

25
cervix
Protect the fetus during pregnancy Opens to form the birth canal
26
vagina
Accepts the penis/sperm during sexual intercourse With the cervix forms the birth canal
27
sperm duct (vas deferens)
transfer sperm during ejaculation
28
prostate gland
secrete fluid containing base, proteins, and fructose into semen
29
urethra
transfer semen during ejaculation and urine during urination
30
penis
penetrate vagina delivers sperm to top of the vagina
31
seminal vesicle
secrete fluid containing base, proteins, and fructose into semen
32
epididymis
store sperm until ejaculation
33
testis
produce sperm and testosterone
34
scrotum
holds testes outside the body to keep low temp.
35
pituatary hormones in menstrual cycle
FSH, LH
36
ovaria hormones in menstrual cycle
estrogen and progesterone
37
Other hormones
HCG, oxytocin
38
Follicular phase
follicles developing in ovary growing egg in each follicle lining of the uterus (endometrium) thickens most developed follicle breaks open → egg released into oviduct other follicles degenerate
39
Luteal phase
follicle wall becomes corpus luteum (in ovary) endometrium develops for implantation of embryo if no fertilization corpus luteum breaks down endometrium shed during menstruation
40
FSH
rises at end of cycle → stimulates development of follicles stimulates secretion of estrogen by follicle wall
41
Estrogen
peaks near end of follicular phase stimulates thickening of endometrium after menstruation stimulates increase in FSH receptors in follicles (produce more estrogen → positive feedback) high levels of estrogen inhibit secretion of FSH (negative feedback) and stimulates LH secretion
42
LH
sudden, sharp peak near end of follicular phase stimulates completion of meiosis in oocyte stimulates partial digestion of follicle wall to allow bursting during ovulation promotes development of follicle wall into corpus luteum after ovulation → corpus luteum secretes estrogen (positive feedback) and progesterone
43
Progesterone
rises at start of luteal phase, then peaks and drops off promotes thickening of endometrium inhibits FSH and LH secretion by the pituitary gland (negative feedback)
44
Follicular phase Day 1-4
menstruation: endometrium shed FSH increases, stimulating follicle development
45
Follicular phase Day 5-14
FSH and follicle stimulates estrogen release estrogen stimulates endometrial thickening estrogen stimulates LH peak in LH causes ovulation (day 14)
46
Luteal phase Day 14-28
fall in LH → corpus luteum forms from now-empty follicle corpus luteum releases progesterone progesterone thickens endometrium and inhibits FSH and LH
47
If no fertilisation/implantation occurs,...
progesterone and estrogen drop, triggering menstruation and FSH release.
48
Some causes of infertility:
Female: Ova not maturing or being released Abnormality in uterus prevents implantation Antibodies in cervical mucus impair sperm Blocked fallopian tubes Male Unable to achieve an erection or normal ejaculation Low sperm count or sperm are abnormal with low motility Blocked vas deferens
49
IVF
Stop normal menstrual cycle (with drugs) Hormone treatments to promote super ovulation Extract multiple eggs from the ovaries Sperm collected, then prepared (via capacitation) and injected into egg Fertilisation occurs externally under controlled conditions (in vitro) Implantation of multiple embryos into uterus (either patient or surrogate) Test for pregnancy after ~ two weeks Mnemonic: SHE’S FIT
50
Hormonal treatments involved in IVF
1. Down-regulation = shutting down of the menstrual cycle by stopping secretion of the pituitary and ovarian hormones; two weeks and allows better control of egg production; done with a drug, commonly in the form of a nasal spray. 2. Superovulation collects multiple eggs from the woman. High doses of FSH are injected over approximately a ten day period to stimulate the development of multiple follicles. 3. When follicles reach 15-20mm in diameter an injection of HCG is given to start maturation process. Approximately 36 hours later, under a general anesthetic, follicles (typically 8-12) are collected from the ovaries. 4. Prepared eggs (removed from the follicles) are combined with sperm in sterile conditions. Successfully fertilised eggs are then incubated before implantation. 5. If fertilized, multiple embryos are placed into the uterus after 48 hours. 6. For approximately two weeks before implantation the woman takes progesterone (which maintains the endometrium), usually in the form of a suppository, to aid implantation. This treatment is continued until pregnancy test, and if positive, until 12 weeks of gestation.
51
Testosterone
Pre-natal development of male genitalia, sperm production, development of male secondary sexual characteristics during puberty.
52
FSH
Stimulates the growth and development of ovarian follicles (bodies containing eggs).
53
LH
Triggers ovulation, the release of the oocyte (egg) from the ovary
54
Estrogen
Pre-natal development of female reproductive organs and female secondary sexual characteristics during puberty. Causes the uterine lining to thicken.