1.1 Introduction to Cells Flashcards

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1
Q

Cell theory states that:

A

All living things are composed of cells (or cell products)
The cell is the smallest unit of life
Cells only arise from pre-existing cells

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2
Q

The cell is the smallest unit of life

A

Specialized structures within cells (organelles) carry out different functions. Organelles cannot survive alone.

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3
Q

Cells only arise from pre-existing cells:

A

Cells multiply through division
All life evolved from simpler ancestors
Mitosis results in genetically identical diploid daughter cells
Meiosis generates haploid gametes (sex cells)

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4
Q

Cells vary considerably in size and shape but they share common features:

A

Cell membrane
Genetic material
Have enzyme-catalysed chemical reactions
Creates energy through chemical reactions that power the cell

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5
Q

striated muscle

A

Muscle cells called fibres can be very long (30mm)
They are surrounded by a single plasma membrane but they are multi-nucleated (many nuclei).

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6
Q

aseptate fungal hyphae

A

challenges the idea that a cell is a single unit.
Fungal hyphae are very large with many nuclei and a continuous cytoplasm
The tubular system of hyphae form dense networks called mycelium
The cytoplasm is continuous along the hyphae with no end cell wall or membrane

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7
Q

giant algae (Acetabularia)

A

Gigantic in size (5-100mm) - one would expect them to be composed of many cells
Complex in form, it consists of three anatomical parts:
Bottom rhizoid (that resembles a set of short roots)
Long stalk
Top umbrella of branches that may fuse into a cap
The single nucleus is located in the rhizoid

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8
Q

Characteristics of Living Things

A

Metabolism - the web of all the enzyme-catalysed reactions in a cell or organism, e.g. respiration
Response - Living things can respond to and interact with the environment
Homeostasis - The maintenance and regulation of internal cell conditions, e.g. water and pH
Growth - Living things can grow or change size / shape
Excretion – the removal of metabolic waste
Reproduction - Living things produce offspring, either sexually or asexually
Nutrition – feeding by either the synthesis of organic molecules (e.g. photosynthesis) or the absorption of organic matter

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9
Q

How does paramecium show the functions of life?

A

Excretion – the plasma membrane control the entry and exit of substances including expulsion of metabolic waste

Metabolism – most metabolic pathways happen in the cytoplasm

Nutrition – food vacuoles contain organisms the parameium has consumed

Homeostasis – contractile vacuole fill up with water and expel I through the plasma membrane to manage the water content

Growth – after consuming and assimilating biomass from food the paramecium will get larger until it divides.

Response – the wave action of the cilia moves the paramecium in response to changes in the environment, e.g. towards food.

Reproduction – The nucleus can divide to support cell division by mitosis, reproduction is often asexual

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10
Q

How does chlorella show the functions of life?

A

Excretion – the plasma membrane control the entry and exit of substances including the difussion out of waste oxygen

Metabolism – most metabolic pathways happen in the cytoplasm

Nutrition – photosynthesis happens inside the chloroplasts to provide the algae with food

Reproduction – The nucleus can divide to support cell division, by mitosis (these cells are undergoing cytokinesis)

Growth – after consuming and assimilating biomass from food the algae will get larger until it divides.

Response – the wave action of the cilia moves the algae in response to changes in the environment, e.g. towards light.

Homeostasis – contractile vacuole fill up with water and expel I through the plasma membrane to manage the water content

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11
Q

Small SA:V ratio

A

Substances cannot enter cell quickly
Waste accumulates
Cells may overheat if metabolism produces heat faster than it is lost

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12
Q

Large SA:V ratio

A

Cell can be more efficient
More SA to supply each unit of volume
Shorter diffusion pathway

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13
Q

Are there cases when large SA:V ratios are disadvantageous?

A

Small, warm-blooded mammals lose heat very quickly with a high SA:V ratio. They need to eat almost constantly!

Desert plants would lose too much water with flat leaves that have a high SA:V ratio. This is why they decrease the SA of leaves by making fatter leaves.

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14
Q

So how do organisms maximise the SA:V ratio?

A

Cells divide rather than grow bigger (also allows cells to specialise)

Folded membranes are used to increase SA (recall the folds in mitochondria)

Folded tissues to increase SA (recall the villi in the small intestine)

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15
Q

Emergence

A

a property observed in livings that occurs when an entity is observed to have properties its parts do not have on their own.

“The whole is greater than the sum of the parts”. Multicellular organisms are capable of completing functions that individual cells could not undertake - this is due to the interaction between component parts (cells) producing new functions.

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16
Q

These specialized cells are more efficient at their function. WHY?

A

They can develop a specialized structure/enzymes to support their function. Ex:
White blood cells, more lysosomes and digestive enzymes to break apart invading organisms and dead cells
Sperm cells, have flagella to help movement

Cell specialization is also called cell differentiation

17
Q

All (diploid) cells of an individual organisms share an

A

identical genome - each cell contains the entire set of genetic instructions for that organism

18
Q

BUT not all genes are

A

expressed (activated) in all cells

19
Q

n (totipotent) embryonic stem cells the entire genome is

A

active

20
Q

Newly formed cells receive signals which deactivate (or more rarely activate)…

A

e.g. a skin cell does not need to be able to produce haemoglobin (the pigment in red blood cells that carries oxygen)

21
Q

When a gene is

A

“switched on” the information is used to create a protein or other gene product.
Development of a cell involves switching on particular genes and expressing them, but not others.

22
Q

Cell differentiation happens because a different sequence of genes is expressed in different cell types. The control of gene expression is the key to

A

development

23
Q

This occurs when a gene is copied, and the information is used to

A

produce a functional protein (transcription and translation)

24
Q

Transcription is regulated by

A

transcription factors (a series of proteins that work together to signal when a gene should be copied)

25
Q

The fewer active genes a cell possesses the more

A

specialised it will become
As a result of gene expression cell differentiation begins: the cell’s metabolism and shape changes to carry out a specialised function.

26
Q

Stem cells are unspecialised cells that can:

A

Can continuously divide and self-replicate
Have the capacity to differentiate into specialised cell types

Stem cells are one of the most active areas of research in biology and medicine today (regenerative medicine)

27
Q

Stem cells have varying levels of potency:

A

Totipotent = can differentiate into any type of cell.

Pluripotent = can differentiate into many types of cell.

Multipotent = can differentiate into a few closely-related types of cell (e.g. blood stem cells can make RBCs, WBCs, platelets)

Unipotent = can regenerate but can only differentiate into their associated cell type (e.g. liver stem cells can only make liver cells).

28
Q

Stargardt’s macular dystrophy

A

The problem
- Affects around one in 10,000 children
Recessive genetic (inherited) condition
The mutation causes an active transport protein on photoreceptor cells to malfunction
The photoreceptor cells degenerate
the production of a dysfunctional protein that cannot perform energy transport
that causes progressive, and eventually total, loss of central vision

The treatment
- Embryonic stem cells are treated to divide and differentiate to become retinal cells
The retinal cells are injected into the retina
The retinal cells attach to the retina and become functional
Central vision improves as a result of more functional retinal cells

The future
- This treatment is still in at the stage of limited clinical trials, but will likely be in usage in the future

29
Q

Leukemia

A

The problem
- Cancer of the blood or bone marrow, resulting in abnormally high levels of poorly-functioning white blood cells.

The treatment
- Hematopoetic Stem Cells (HSCs) are harvested from bone marrow, peripheral blood or umbilical cord blood
Chemotherapy and radiotherapy used to destroy the diseased white blood cells
New WBCs need to be replaced with healthy cells.
HSCs are transplanted back into the bone marrow
HSCs differentiate to form new healthy white blood cells

The benefit
- The use of a patient’s own HSCs means there is far less risk of immune rejection than with a traditional bone marrow transplant.

30
Q

stem cell sources: Embryo

A

Differentiation
- Can differentiate into any cell type

Genetic damage
- Less chance of genetic damage than adult cells

Compatibility
- Stem cells are not genetically identical to the patient

31
Q

stem cell sources: Cord blood

A

Differentiation
- Limited capacity to differentiate (without inducement only naturally divide into blood cells)

Genetic damage
- Less chance of genetic damage than adult cells

Compatibility
- Fully compatible with the patient as the stem cells are genetically identical

32
Q

stem cell sources: Adult

A

Differentiation
- Limited capacity to differentiate (dependent on the source tissue)

Genetic damage
- Due to accumulation of mutations through the life of the adult genetic damage can occur

Compatibility
- Fully compatible with the patient as the stem cells are genetically identical

33
Q

Arguments for Therapeutic Use of Stem Cells

A

Stem cell research may pave the way for future discoveries and beneficial technologies

May be used to cure serious diseases or disabilities with cell therapy (replacing bad cells with good ones)

Transplants are less likely to be rejected
Transplants do not require the death of another human

Stem cells can be taken from embryos that have stopped developing and would have died anyway

Cells are taken at a stage when the embryo has no nervous system and can arguably feel no pain

Stem cells can be created without the need for fertilisation and destruction of ‘natural’ human embryos – induced pluripotent stem cells