6 Immunodeficiency Flashcards
Genetic defects that result in an increased susceptibility to infection. Frequently manifested in youth. May result from defects in leukocyte maturation/activation.
Primary/Congenital Immunodeficiences
Increased susceptibility to infection due to malnutrition, disseminated cancer, immunosuppressive drugs, infection of immune cells.
Secondary/Acquired Immunodeficiencies
The types of _____ can predict the type of immunodeficiency
Recurring infections
Deficient ____ immunity usually results in increased susceptibility to infection by pyogenic bacteria
Humoral
X-linked agammaglobulinemia (XLA) is associated with a loss of function of ____ that is important for pre-B cell expansion and maturation into Ig-expressing B cells
Bruton Tyrosine Kinase
In X-linked immunodeficiency with hyper-IgM, B cells are not signaled by the ____ to go through isotype switching and only produce IgM
T cell
The treatment for humoral immunodeficiency is ____
The treatment for cell-mediated immunodeficiency is ____
Routine: Prophylactic antibiotics and/or gamma-globulin therapy
Practically non-existent
Deficient ____ immunity usually results in increased susceptibility to viruses and other intracellular pathogens
Cell-mediated
DiGeorge’s syndrome is a developmentally-related disease associated with tissue morphogenesis- the ____ does not develop so T cell percentage is decreased.
Thymus
Current treatments of immunodeficiencies have two aims:
- Minimize/control infections
- Replace defective/absent components of immune system by adoptive transfer and/or transplantation.
- Passive Immunization with pooled gamma globulin
- Bone marrow transplantation
HIV is a secondary/acquired immunodeficiency that causes the destruction of ____ tissue and depletion of ____ cells
Lymphoid
CD4 T cells
