6 - Epilepsy Flashcards

1
Q

What is epilepsy?

A
  • associated with reduced GABA levels which leads to abnormal cell communication
  • less stimulation is required for neurones to fire
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2
Q

What is a febrile seizure?

A
  • children who have a fever
  • managed acutely
  • presents with fever, eyes rolling upwards, loss of consciousness, jerky movements, face may turn red or blue
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3
Q

What is the management of febrile seizures?

A
  • cool hot children who are above 38 degrees
  • paracetamol and ibuprofen
  • remove clothes
  • cool sponging or bath
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4
Q

What are the different types of generalised epilepsy?

A
  • tonic/clonic
  • petit mal (absence)
  • myoclonic/atonic
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5
Q

What are the different types of partial epilepsy?

A
  • simple partial
  • complex partial
  • simple sensory
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6
Q

What are the triggers of epilepsy?

A
  • idiopathic
  • trauma (head injury)
  • CNS disease eg tumour or stroke, meningitis, encephalitis
  • social (alcohol, hypoglycaemia, flashing lights)
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7
Q

How does the epileptic focus affect presentation?

A
  • central focus causes primary generalised epilepsy
  • cortical focus causes partial epilepsy
  • can present by seeing/hearing something that isn’t there, is generated by seizure
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8
Q

Describe a tonic clonic seizure.

A
  • prodromal aura (awareness of onset)
  • loss of consciousness and continence
  • tonic = contraction of voluntary muscle
  • clonic = contraction and relaxation of muscles, spasm
  • post-ictal drowsiness last 1-3 mins
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9
Q

What is status epilepticus?

A
  • recurrent seizures
  • very dangerous as breathing muscles are voluntary and do not function during seizure
  • can result in hypoxia
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10
Q

Describe a petit mal seizure.

A
  • absence seizure
  • short lived episodes of 5-15 seconds
  • loss of awareness (eyelids flutter, vacant stare, stop activity, loss of response)
  • common in childhood
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11
Q

What are the effects of tonic clonic seizures?

A
  • injury from fall or spasms
  • asphyxia
  • sudden death
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12
Q

What are risk factors for tonic clonic epilepsy?

A
  • poor medication compliance
  • alcohol
  • GA agents
  • tricyclics (antidepressants)
  • stress and fatigue
  • infection
  • menstruation
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13
Q

Describe a motor partial seizure.

A
  • motor seizure localised to one region of body
  • can spread eg move up arm (known as Jacksonian seizure)
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14
Q

Describe a sensory partial seizure.

A
  • can be visual, auditory, taste, smell changes that are not caused by external stimuli
  • hallucinations
  • can cause deja vu
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15
Q

Describe a complex partial seizure.

A
  • automatism
  • unaware of movement occurring
  • repetitive purposeless movement including lip smacking and grimacing
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16
Q

What drugs are used in the prevention of tonic clonic epilepsy?

A
  • valproate
  • carbamazepine
  • phenytoin
17
Q

What drugs are used in the prevention of petit mal epilepsy?

A

Levitiracetam

18
Q

What is the emergency management of epilepsy?

A
  • supportive treatment only is unconscious eg airway and oxygen
  • status epilepticus requires benzodiazepines
19
Q

How does valproate treat epilepsy?

A

GABA transaminase inhibitor (prevents breakdown of GABA)

20
Q

How do benzodiazepines treat epilepsy?

A

GABA receptor action is enhanced

21
Q

How does carbamazepine treat epilepsy?

A

Stabilises sodium channels

22
Q

What surgical options are there for epilepsy?

A
  • removal of focal neurological lesions eg tumours
  • partial lobectomy if uncontrollable with medication
23
Q

How does epilepsy affect dentistry?

A
  • complication of fits (soft tissue injury, dental fracture)
  • gingival hyperplasia (phenytoin)
  • bleeding tendency (valproate)
  • folate deficiency
  • treat at low risk times
24
Q

How do you assess if a patient is at risk of seizures?

A
  • ask when last 3 fits took place
  • ask about compliance with medication
  • ask about changes in medication