6. Endocrine Tissues Flashcards

1
Q

Where is the anterior pituitary and what does it secrete?

A

Base of brain

TSH, TH, FSH, LH, GH, prolactin, MSH

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2
Q

Where is the posterior pituitary and what does it secrete?

A

Base of brain

ADH, vasopressin, oxytocin

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3
Q

Where is the thyroid gland and what does it secrete?

A

Anterior to trachea (2 lobes)

Thyroxine (T4), triodothyroinine (T3)

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4
Q

Where is the parathyroid gland and what does it secrete?

A

Lie on dorsal surface of thyroid gland

Parathormone (PTH)

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5
Q

Where are the adrenal glands and what do they secrete?

A

Top of each kidney

Context secretes corticosteroids, small amounts of androgen, estrogen and progestin

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6
Q

Where is the pancreas and what does it secrete?

A

Left of and behind stomach
Exocrine secretes digestive enzymes into duodenum
Endocrine has islets of langerhans, alpha cells produce glucagon, beta cells secrete insulin

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7
Q

What are the 3 types of hormones?

A

Glycoproteins (peptide hormones)
Steroid hormones
Amino acid derived hormones

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8
Q

What does the hypothalamus control?

A
Thermoregulation
Plasma osmolality
Heart rate, blood pressure
Feeding, regulation of GI tract 
Circadian rhythms
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9
Q

What does the hypothalamus produce?

A

Vasopressin (ADH) and oxytocin - travel to posterior pituitary through nerves
Six hormones that travel to anterior pituitary

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10
Q

What is a portal system?

A

Blood travels through 2 sets of smaller vessels before returning to heart

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11
Q

Give 2 examples of the portal system in the body

A

Hypothalamo-hypophyseal portal system between hypothalamus and anterior pituitary
Liver (hepatic)

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12
Q

What happens in the development of endocrine system at 5 weeks?

A
Pituitary develops
Thyroid develops
Parathyroid and thymus develops 
Pancreas develops
Adrenals develop
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13
Q

What mode of secretion do pituitary hormones use?

A

Constitutive and regulated merocrine secretion

This is why there is always a small concentration of these hormones in the blood

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14
Q

What does hyperthyroidism mean?

A

High T3 or T4

Has low TSH

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15
Q

What does hypothyroidism mean?

A

Low T3 or T4

High TSH

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16
Q

What causes the TSH levels in hypothyroidism and hyperthyroidism?

A

They are due to negative feedback loop on TRH production and release at the hypothalamus

17
Q

What happens to parafollicular cells in development?

A

They are neuroendocrine cells that migrate into thyroid during thyroid development in embryo

18
Q

What is the role of parafollicular cells?

A

Produce peptide hormone thyrocalcitonin
Monitors plasma calcium concentration and decreases levels
Inhibits osteoclast activity in bone

19
Q

What is the role of the parathyroid gland?

A

Constantly monitors plasma calcium concentrations

20
Q

What happens if plasma calcium low?

A

Parathyroid gland detects
PTH is made
PTH causes bones to release calcium into blood and absorb more from GI tract
Negative feedback loop

21
Q

What is the adrenal medulla composed of?

A

Parenchyma of epithelioid cells called chromaffin cells

Many myelinated presynaptic sympathetic nerve fibres

22
Q

What is the outer layer of the adrenal cortex?

A

Zona glomerulosa

Aldosterone regulates BP

23
Q

What is the middle of the adrenal cortex?

A

Zona fasciculta

Glucocorticoids (cortisol) mobilise fats, proteins and carbs

24
Q

What is the inner layer of the adrenal cortex?

A

Zona reticularis

Androgen precursors