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Immunosero Lec (Prelim) > 6. Complement proteins > Flashcards

6. Complement proteins Flashcards

1
Q

Non specific humoral factors that consist of complex series of more than 30 soluble and cell bound proteins

A

Complement proteins

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2
Q

What is the main function of complement proteins?

A

Eliminates or destroy cells that triggers complement activation

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3
Q

Who coined complement?

A

Paul Ehrlich

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4
Q

Who elucidated the function of complement proteins?

A

Jules bordet

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5
Q

What are the major fraction for complement protein?

A

Beta 1 and beta 2 globulin

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6
Q

How complement proteins eliminated cells?

A

Lysis

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7
Q

How many major complement proteins?

A

9 (C1 - C9)

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8
Q

What is the sequence for the Classical pathway?

A

C1, C4, C2, C3, C5, C6, C7, C8, C9

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9
Q

How is peptide chain being assigned with what language?

A

Greek Letter (Gamma greek sign)

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10
Q

How is peptide chain being assigned with what language?

A

Greek Letter (Gamma greek sign)

C3:
C3 alpha
C3 Beta
C3 Gamma

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11
Q

Activated complement proteins are assigned in _________ letters

A

Lower case

Ex:
C3a
C3b

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12
Q

What is the end result for classical pathway?

A

Lysis of foreign cells

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13
Q

What are the 3 recognition unit for classical pathway?

A

C1q
C1r
C1s

(Tri molecular complex)

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14
Q

Largest C protein which initiates C activation by binding to 2 adjacent Fc portion of an antigen-bound IgM or IgG

Like a Docking site

A

C1q

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15
Q

Activation Relys on in the presence of immune complex (IgM or IgG)

A

Immune complex dependent

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16
Q

What immunoglobulin is the best complement activator?

A

IgM

because of pentameric

IgG on the otherhand need 2 to have 2 Fc

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17
Q

Recognition unit for proteolytic zymogen

A

C1r

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18
Q

Recognition unit that is a

zymogen when free,
esterase when bound

Responsible for cleaving or activating the next complement protein

A

C1s

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19
Q

Tri molecular complex is held together by?

A

Calcium ions

Ca2+

20
Q

Activation units what is the 1st activation

A

C4

21
Q

Function of C4?

A

Activates C1s to cleaves C4alpha

22
Q

What is the resulting fragments?

A

C4a and C4b

23
Q

What is C4a?

This triggers inflammatory cells causing degranulation such as histamine

A

anaphylatoxin

24
Q

what is C4b?

A

Attaches to cell membrane

(of foreign cells)

25
Q

NOTE: C4 composed 3 peptides (Alpha, Beta, Gamma)

A
26
Q

What is the 2nd activation unit?

This binds to C4b and is cleaved

A

C2

27
Q

C2 is activated by?

A

C1s

28
Q

What is the resulting fragments for C2?

A

C2a, and C2b

29
Q

remains w/ C4b w/c forms ____________ or ___________

A

C4b2a or C3 convertase

30
Q

C3 convertase was made in the presence of?

A

Magnesium

31
Q

Most abundant complement protein in serum which serves as the merging point of the activation pathway which lead to common pathway?

Secreted by macrophages

A

C3

32
Q

C3 is cleaved by?

A

C3 convertase

33
Q

What are the resulting fragments of C3?

A

C3a and C3b

34
Q

What is the function C3a?

A

anaphylatoxin

35
Q

What is the function of C3b?

A

Binds to C42a to form C4b2a3b (C5 convertase)

36
Q

Can act to opsonins independently?

A

C3b

37
Q

1st membrane attack unit?

A

C5

38
Q

What are the resulting fragment for C5?

A

C5a and C5b

39
Q

Resulting fragments of C5 that serves as a chemoattractant or chemotactic factor and anaphylatoxin

A

C5a

40
Q

Attracts the migration of phagocytes

A

Chemotactic factor

41
Q

Resulting in fragments of C5 that attaches to cell surface

Docks for membrane attack units (Susunod an proteins)

A

C5b

42
Q

2nd and the 3rd membrane attack unit respectively

A

C6 and C7

43
Q

Attaches to C5b to form the first membrane attack complex which is?

A

C5b67

44
Q

Inserted to the cell membrane creating pores or erosions

A

C8 and C9

45
Q

When C8 attaches to C5b67?

A

slow lysis

46
Q

What happen when C9 attaches?

A

C5b6789 = fast lysis

Immunosero Lec (Prelim) (8 decks)

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