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Immunosero Lec (Prelim) > 4. Antibodies > Flashcards

4. Antibodies Flashcards

1
Q

Also known as immunoglobulin or gamma globulin

Substances produced in response to an immunogenic stimulation that are capable or spcific interaction with the provoking immunogen

A

Antibodies

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2
Q

Membrane bound antibodies serve as a?

A

Receptor

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3
Q

What immunoglobulin activates complement proteins?

A

IgM and IgG

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4
Q

Who proposed Side chain theory?

A

Paul Ehrlich

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5
Q

Certain cells have specific receptors for antigen that were present prior to antigen

A

Side chain theory

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6
Q

Who propoesed instructive theory?

A

Felix Haurowitz

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7
Q

Antibody-generating cells can produce a generalized antibody

A

Instructive theory

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8
Q

Who proposed Clonal Selection Theory

A

Niels Jerne and Macfalane Burnett

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9
Q

Individual lymphocytes are genetically preprogrammed to generate a specific antibody

Major drawback is the consideration of genetic basis

A

Clonal selection theory

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10
Q

Proposed that genes coding for the constant and variable Ig regions are separate

A

Dreyer and Bennet

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11
Q

Discovered of genetic mechanism of antibody diversity

A

Susumu Tonegawa

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12
Q

Codes for heavy chains?

A

Chromosome 14

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13
Q

Codes for Lamda light chains

A

Chromosome 22

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14
Q

A Classic monomeric antibody consists of?

A

2 identical light chains
2 identical heavy chains

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15
Q

Each light chain is cavalently bonded to a heavy chain by?

Also heavy chain are covalently bonded to each other by?

A

Disulfide bonds

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16
Q

Unique amino acid sequence that is common to all Ig molecules of a given class in each species?

A

Isotype

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17
Q

Minor variation is heavy chain sequence that are present in some individuals but not to others

A

Allotype

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18
Q

5 types of Isotypes?

A

IgA
IgE
IgD
IgG
IgM

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19
Q

Variable portion of each chain differ from each person

A

Idiotypic difference

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20
Q

Properties shared by all antibody type?

A

Recognition and binding of antigen

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21
Q

Recognition domain; combined VH and VL

It is where antigen/Epitope bind

A

Paratope

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22
Q

Biological activity of the antibody

A

CH

23
Q

Enzymatic treatment: Yields 3 fragments (2 fragment antigen binding, 1 fragment crystallizable)

A

Papain treatment

24
Q

Enzymatic treatment: yielded two fragments: 2 Fab units in a single structure

A

Pepsin treatment

25
Q

Similar to Fc portion but is disintegrated to smaller pieces

A

Pepsin treatment

26
Q

Also known as Macroglobulin (Biggest); confined in the intravascular pool

Mew heavy chain

5 monomeric Ab structures joined by a

A

IgM

27
Q

How many antigens can IgM binds?

A

10

28
Q

Primary immune response antibody?

A

IgM

29
Q

Most efficient in Complement pathway?

A

IgM

30
Q

The only membrane bound Ab?

A

IgD and IgM

31
Q

Predominant immunoglobulin in humans?

A

IgG

32
Q

Has the longest half life of all Ig

A

IgG 23 days

33
Q

The “Immune” antibody of Immunoglobulin

A

IgG

34
Q

Plays in a significant role in HDFN?

A

IgG

35
Q

Participates more in precipitation for immunoglobulins

A

IgG (Precipitins)

36
Q

Most disulfide bonds in IgG

Most efficient complement binding?

A

IgG3 (11 S-S bonds)

37
Q

The only IgG cannot cross the Placenta?

A

IgG2

38
Q

Immunoglobulin best in agglutination reactions?

A

IgM

39
Q

Immunoglobulin best in precipitation reaction?

A

IgG

40
Q

Joined by J chain and has a secretory component

A

IgA

41
Q

IgA that is Dimeric?

Most significant IgA?

A

IgA2

42
Q

Has Mucosal immune defencse

A

IgA2

43
Q

IgA found in the serum

A

IgA1

44
Q

All IgA cannot do complement fixation?

A

TRUE

45
Q

Can activate alternative complement pathway?

A

IgA

46
Q

Can activate classical complement pathway

A

IgM

47
Q

Cold reacting antibody?

A

IgM

48
Q

Warm reacting antibody?

A

IgG

49
Q

Immunoglobulin that is involved in parasitic infection

A

IgE

50
Q

Attaches to inflammatory cells fue to high affinity FcER1?

A

IgE

51
Q

Concentration for Immunoglobulin

A

GAMDE

52
Q

Size for Immunoglobulin

A

MAGED

53
Q

Antibodies derived from a single parent antibody-producing cell that has been reproduced multiple times forming a clone

A

Monoclonal antibodies

54
Q

Who proposed Monoclonal antibodies?

A

Cesar Milstein and Georges Kohler

Immunosero Lec (Prelim) (8 decks)

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