4. Antibodies

Question 1

Also known as immunoglobulin or gamma globulin

Substances produced in response to an immunogenic stimulation that are capable or spcific interaction with the provoking immunogen

Answer 1

Antibodies

Question 2

Membrane bound antibodies serve as a?

Answer 2

Receptor

Question 3

What immunoglobulin activates complement proteins?

Answer 3

IgM and IgG

Question 4

Who proposed Side chain theory?

Answer 4

Paul Ehrlich

Question 5

Certain cells have specific receptors for antigen that were present prior to antigen

Answer 5

Side chain theory

Question 6

Who propoesed instructive theory?

Answer 6

Felix Haurowitz

Question 7

Antibody-generating cells can produce a generalized antibody

Answer 7

Instructive theory

Question 8

Who proposed Clonal Selection Theory

Answer 8

Niels Jerne and Macfalane Burnett

Question 9

Individual lymphocytes are genetically preprogrammed to generate a specific antibody

Major drawback is the consideration of genetic basis

Answer 9

Clonal selection theory

Question 10

Proposed that genes coding for the constant and variable Ig regions are separate

Answer 10

Dreyer and Bennet

Question 11

Discovered of genetic mechanism of antibody diversity

Answer 11

Susumu Tonegawa

Question 12

Codes for heavy chains?

Answer 12

Chromosome 14

Question 13

Codes for Lamda light chains

Answer 13

Chromosome 22

Question 14

A Classic monomeric antibody consists of?

Answer 14

2 identical light chains
2 identical heavy chains

Question 15

Each light chain is cavalently bonded to a heavy chain by?

Also heavy chain are covalently bonded to each other by?

Answer 15

Disulfide bonds

Question 16

Unique amino acid sequence that is common to all Ig molecules of a given class in each species?

Answer 16

Isotype

Question 17

Minor variation is heavy chain sequence that are present in some individuals but not to others

Answer 17

Allotype

Question 18

5 types of Isotypes?

Answer 18

IgA
IgE
IgD
IgG
IgM

Question 19

Variable portion of each chain differ from each person

Answer 19

Idiotypic difference

Question 20

Properties shared by all antibody type?

Answer 20

Recognition and binding of antigen

Question 21

Recognition domain; combined VH and VL

It is where antigen/Epitope bind

Answer 21

Paratope

Question 22

Biological activity of the antibody

Answer 22

CH

Question 23

Enzymatic treatment: Yields 3 fragments (2 fragment antigen binding, 1 fragment crystallizable)

Answer 23

Papain treatment

Question 24

Enzymatic treatment: yielded two fragments: 2 Fab units in a single structure

Answer 24

Pepsin treatment

Question 25

Similar to Fc portion but is disintegrated to smaller pieces

Answer 25

Pepsin treatment

Question 26

Also known as Macroglobulin (Biggest); confined in the intravascular pool Mew heavy chain 5 monomeric Ab structures joined by a

Answer 26

IgM

Question 27

How many antigens can IgM binds?

Answer 27

10

Question 28

Primary immune response antibody?

Answer 28

IgM

Question 29

Most efficient in Complement pathway?

Answer 29

IgM

Question 30

The only membrane bound Ab?

Answer 30

IgD and IgM

Question 31

Predominant immunoglobulin in humans?

Answer 31

IgG

Question 32

Has the longest half life of all Ig

Answer 32

IgG 23 days

Question 33

The "Immune" antibody of Immunoglobulin

Answer 33

IgG

Question 34

Plays in a significant role in HDFN?

Answer 34

IgG

Question 35

Participates more in precipitation for immunoglobulins

Answer 35

IgG (Precipitins)

Question 36

Most disulfide bonds in IgG Most efficient complement binding?

Answer 36

IgG3 (11 S-S bonds)

Question 37

The only IgG cannot cross the Placenta?

Answer 37

IgG2

Question 38

Immunoglobulin best in agglutination reactions?

Answer 38

IgM

Question 39

Immunoglobulin best in precipitation reaction?

Answer 39

IgG

Question 40

Joined by J chain and has a secretory component

Answer 40

IgA

Question 41

IgA that is Dimeric? Most significant IgA?

Answer 41

IgA2

Question 42

Has Mucosal immune defencse

Answer 42

IgA2

Question 43

IgA found in the serum

Answer 43

IgA1

Question 44

All IgA cannot do complement fixation?

Answer 44

TRUE

Question 45

Can activate alternative complement pathway?

Answer 45

IgA

Question 46

Can activate classical complement pathway

Answer 46

IgM

Question 47

Cold reacting antibody?

Answer 47

IgM

Question 48

Warm reacting antibody?

Answer 48

IgG

Question 49

Immunoglobulin that is involved in parasitic infection

Answer 49

IgE

Question 50

Attaches to inflammatory cells fue to high affinity FcER1?

Answer 50

IgE

Question 51

Concentration for Immunoglobulin

Answer 51

GAMDE

Question 52

Size for Immunoglobulin

Answer 52

MAGED

Question 53

Antibodies derived from a single parent antibody-producing cell that has been reproduced multiple times forming a clone

Answer 53

Monoclonal antibodies

Question 54

Who proposed Monoclonal antibodies?

Answer 54

Cesar Milstein and Georges Kohler