56 - Bone and joint infections Flashcards
Osteomyelitis is…
Infection of bone
Heterogenous disease
Difficult to diagnose and treat
Pathogenesis of osteomyelitis
Haematogenous - bacteria in blood go to bone e.g. endocarditis
Contiguous-focus - spread from adjacent area of infection
Direct inoculation - trauma or surgery
Classification of osteomyelitis
Stage 1 Medullary (necrosis of medullary contents - haematogenous)
Stage 2 superficial - necrosis localised to exposed surface
Stage 3 localised - full thickness cortical sequestation
Stage 4 diffuse - extensive, unstable bone
Osteomyelitis - clinical presentation
Pain Soft tissue swelling Erythema Warmth Localised tenderness Reduced movement of affected limb Systemic upset
Osteomyelitis - causative organisms
Staph. aureus (most common 60%) Steptococci - A or B Enterococci Gram -ve bacilli e.g. salmonella Anaerobes Mycobacterium tuberculosis
Osteomyelitis - investigations
gold standard - culture and histology of bone biopsy / needle aspirates
Blood cultures 50% positive
Superificial swabs are of limited value
Leukocytosis - not diagnostic
CRP - usually raised
Osteomyelitis - therapy
Antimicrobials +/- surgery
Avoid empirical antimicrobial therapy
Give targeted ATX therapy
IV ATX initially given to ensure compliance and optimal bone levels as penetration to bone is low
Osteomyelitis - drug therapy
Clindamycin Ciprofloxacin Vancomycin B-lactams Gentamicin
Flucloxacillin IV - agent of choice for S.aureus
Septic arthritis - definition
Inflammatory rxn in joint space caused by infection resulting from direct invasion of a joint
Septic arthritis - classification system
Native joint infection vs prosthetic joint infection
Septic arthritis - pathogenesis
Organisms enter via haematogenous or trauma
Synovial tissue is highly vascular and lacks basement membrane allowing seeding
Cartilage erodes narrowing joint space
Septic arthritis - predisposing factors
Rheumatoid arthritis
Trauma
IV drug use
Immunosuppressive disease
Septic arthritis - prosthetic joint infection
Organisms enter a joint via the blood
Joint prosthesis and cement provide a surface for bacterial attachment
Polymorph infiltration results in tissue damage instability of the prosthesis
Septic arthritis - clinical presentation
Joint - pain, swelling, tenderness, redness and limited movement
Systemic upset - fever, chills, night sweats
Septic arthritis - causative organisms
Bacteria
Fungi
Parvovirus B19, rubella, mumps